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ROBO2
Description
roundabout guidance receptor 2
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Membrane
Axolemma
Extracellular Exosome
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Identical Protein Binding
Biological Process
Metanephros Development
Ureteric Bud Development
Heart Induction
Outflow Tract Septum Morphogenesis
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Formation
Chemotaxis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Nervous System Development
Axon Guidance
Central Nervous System Development
Brain Development
Axon Midline Choice Point Recognition
Olfactory Bulb Interneuron Development
Cell Differentiation
Retinal Ganglion Cell Axon Guidance
Cellular Response To Hormone Stimulus
Tube Development
Aorta Development
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Axonogenesis
Negative Regulation Of Negative Chemotaxis
Negative Regulation Of Synapse Assembly
Ventricular Septum Morphogenesis
Apoptotic Process Involved In Luteolysis
Cell-cell Adhesion
Pathways
Signaling by ROBO receptors
Signaling by ROBO receptors
Regulation of commissural axon pathfinding by SLIT and ROBO
Regulation of cortical dendrite branching
Regulation of expression of SLITs and ROBOs
ROBO receptors bind AKAP5
Formation of the ureteric bud
Drugs
Diseases
Vesicoureteral reflux
GWAS
Bell's palsy (
33602968
)
Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome (
31005965
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
30696823
)
Cortical surface area (MOSTest) (
32665545
)
Expressive vocabulary in infants (
25226531
)
Familial lung adenocarcinoma (
29924316
)
Gut microbiota alpha diversity (Chao1 index) (
33208821
)
Gut microbiota alpha diversity (PD_whole_tree index) (
33208821
)
Hand grip strength (
29691431
)
Hip circumference (
28552196
)
LDL cholesterol levels in HIV infection (
33109212
)
Left-handedness (
32989287
)
Metabolite levels (
23823483
)
Metabolite levels (5-HIAA/ MHPG Ratio) (
23319000
)
Morning person (
30696823
)
Periodontitis (PAL4Q3) (
24024966
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Response to ketamine in bipolar disorder or major depression (dissociation effects) (
30552317
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Type 2 diabetes (
30297969
)
Interacting Genes
18 interacting genes:
BNIP3L
CENPU
CPE
GPR152
HLA-DPB1
NR1H2
NR4A1
OLFM2
PPP1R1B
RDH11
ROBO1
RPS6KA5
SLIT2
SLIT3
SSRP1
TMEM237
TRIM13
UBQLN4
Entrez ID
6092
HPRD ID
11895
Ensembl ID
ENSG00000185008
Uniprot IDs
A0A8Q3SIU0
A0A8Q3SIW8
A0A8Q3WLE3
A0A994J7I9
F8W703
H7C4J7
H7C4U9
H7C4W9
Q9HCK4
PDB IDs
1UEM
1UJT
2EDJ
5NOI
6I9S
6IAA
Enriched GO Terms of Interacting Partners
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Roundabout Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration
Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Response To Cytokine Stimulus
Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration
Apoptotic Process Involved In Luteolysis
Blood Vessel Endothelial Cell Migration
Aortic Valve Morphogenesis
Ventricular Septum Morphogenesis
Regulation Of Negative Chemotaxis
Negative Chemotaxis
Roundabout Binding
Response To Cortisol
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Heart Valve Morphogenesis
Regulation Of Cytokine-mediated Signaling Pathway
Cardiac Septum Morphogenesis
Axon Extension Involved In Axon Guidance
Neuron Projection Guidance
Axon Guidance
Endothelial Cell Migration
Pulmonary Valve Morphogenesis
Chemotaxis
Locomotion
Regulation Of G Protein-coupled Receptor Signaling Pathway
Apoptotic Process Involved In Development
Regulation Of Macroautophagy
Positive Regulation Of Secretion Of Lysosomal Enzymes
Histone H2AS1 Kinase Activity
Induction Of Negative Chemotaxis
Corticospinal Neuron Axon Guidance Through Spinal Cord
Axon Extension
Signal Transduction
Negative Regulation Of Chemotaxis
Transport Vesicle Membrane
Nuclear Receptor Activity
Neuron Projection Development
Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of High-density Lipoprotein Particle Assembly
Positive Regulation Of Pancreatic Juice Secretion
Histone H3S28 Kinase Activity
Negative Regulation Of Retinal Ganglion Cell Axon Guidance
Aldehyde Dehydrogenase (NADP+) Activity
11-cis-retinol Dehydrogenase (NADP+) Activity
Nuclear Proteasome Complex
Protein Localization To Secretory Granule
Negative Regulation Of Negative Chemotaxis
Positive Regulation Of Axonogenesis
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