ROBO2 and TRIM13

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ROBO2	TRIM13
Gene Name		roundabout, axon guidance receptor, homolog 2 (Drosophila)	tripartite motif containing 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis	Signal Transduction Anatomical Structure Morphogenesis Response To Gamma Radiation Positive Regulation Of Cell Death Positive Regulation Of Macroautophagy ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
Drugs			Etorphine Diprenorphine Dihydromorphine
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)	Height ( 23563607)
Protein-Protein Interactions		16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4	4 interactors: ARHGDIA GMCL1 ROBO2 UBE2D2
Entrez ID		6092	10206
HPRD ID		11895	10414
Ensembl ID		ENSG00000185008	ENSG00000204977
Uniprot IDs		Q9HCK4	O60858
PDB IDs		1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death	Positive Regulation Of Axonogenesis Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Positive Regulation Of Neuron Projection Development Regulation Of Negative Chemotaxis Negative Regulation Of Locomotion Luteolysis Axon Midline Choice Point Recognition Positive Regulation Of Cell Projection Organization Axon Choice Point Recognition Positive Regulation Of Neuron Differentiation Olfactory Bulb Interneuron Development Regulation Of Neuron Projection Development Positive Regulation Of Neurogenesis Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Olfactory Bulb Interneuron Differentiation Positive Regulation Of Cell Development Negative Regulation Of Synapse Assembly Regulation Of Neuron Differentiation Retinal Ganglion Cell Axon Guidance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chemotaxis Apoptotic Process Involved In Development Regulation Of Locomotion Regulation Of Neurogenesis Forebrain Neuron Development Neuron Recognition Protein K48-linked Ubiquitination Multicellular Organismal Reproductive Process Olfactory Bulb Development Multicellular Organism Reproduction Semaphorin-plexin Signaling Pathway Regulation Of Cell Development Positive Regulation Of Cell Differentiation Olfactory Lobe Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Rho Protein Signal Transduction Regulation Of Synapse Assembly Forebrain Neuron Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Axonogenesis Reproduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Forebrain Generation Of Neurons
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	anchored autophagy clonogenic dysregulation e3 endoplasmic essential hence ikk interacts kappab ligase modification modulates nemo neurodegenerative nf opposite regulator represses repression resident reticulum ring steps stimuli translational turnover ubiquitination
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	anchored autophagy clonogenic dysregulation e3 endoplasmic essential hence ikk interacts kappab ligase modification modulates nemo neurodegenerative nf opposite regulator represses repression resident reticulum ring steps stimuli translational turnover ubiquitination
Tagcloud (Intersection) ?