SLIT2 and ROBO1

Number of citations of the paper that reports this interaction (PMID 10102268)
168

Data Source:
HPRD (in vivo)

		SLIT2	ROBO1
Gene Name		slit homolog 2 (Drosophila)	roundabout, axon guidance receptor, homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma
	Molecular Function	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Chemorepellent Activity Roundabout Binding	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding
	Biological Process	Metanephros Development Ureteric Bud Development In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Smooth Muscle Cell Migration Single Organismal Cell-cell Adhesion Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Dorsal/ventral Axon Guidance Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Mammary Duct Terminal End Bud Growth Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
Drugs
Diseases
GWAS		Echocardiographic traits ( 17903301)	Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: GPC1 ROBO1 ROBO2 UBC	8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3
Entrez ID		9353	6091
HPRD ID		04776	03890
Ensembl ID		ENSG00000145147	ENSG00000169855
Uniprot IDs		O94813	Q1RMC8 Q9Y6N7
PDB IDs		2V70 2V9S 2V9T 2WFH	2EO9 2V9Q 2V9R 2V9T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Negative Chemotaxis Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Olfactory Bulb Interneuron Differentiation Negative Regulation Of Chemotaxis Forebrain Neuron Development Neuron Recognition Axon Guidance Olfactory Bulb Development Olfactory Lobe Development Forebrain Neuron Differentiation Axonogenesis Axon Development Positive Regulation Of Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Forebrain Generation Of Neurons Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cellular Response To Growth Factor Stimulus Central Nervous System Neuron Development Neuron Projection Development Cell Recognition Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Regulation Of Chemotaxis Neuron Development Regulation Of Axonogenesis Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Heparan Sulfate Proteoglycan Catabolic Process Cell Death Death Cell Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Negative Regulation Of Signal Transduction Neuron Differentiation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Projection Organization Pathogenesis Apoptotic Process Involved In Luteolysis Proteoglycan Catabolic Process Roundabout Signaling Pathway Negative Regulation Of Signaling	Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis
Tagcloud ?		146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs	adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Difference) ?		146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs	adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Intersection) ?