ROBO2 and PPP1R1B

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		ROBO2	PPP1R1B
Name		roundabout guidance receptor 2	protein phosphatase 1 regulatory inhibitor subunit 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome	Nucleus Cytoplasm Cytosol Neuronal Cell Body
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion	Response To Amphetamine DNA-templated Transcription Signal Transduction Negative Regulation Of Female Receptivity Locomotory Behavior Visual Learning Intracellular Signal Transduction Response To Morphine Behavioral Response To Cocaine Cellular Response To Cocaine
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud	DARPP-32 events DARPP-32 events
Diseases		Vesicoureteral reflux	None
GWAS		Bell's palsy ( 33602968 ) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 ) Body size at age 10 ( 32376654 ) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cortical surface area (MOSTest) ( 32665545 ) Expressive vocabulary in infants ( 25226531 ) Familial lung adenocarcinoma ( 29924316 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Hand grip strength ( 29691431 ) Hip circumference ( 28552196 ) LDL cholesterol levels in HIV infection ( 33109212 ) Left-handedness ( 32989287 ) Metabolite levels ( 23823483 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Morning person ( 30696823 ) Periodontitis (PAL4Q3) ( 24024966 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 30297969 )	Asthma ( 31619474 31959851 ) Estimated glomerular filtration rate ( 31015462 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Refractive error ( 32231278 ) Ulcerative colitis ( 20228799 )
Novel Interactors		None recorded	1 novel interactors: FBXL20
Interacting Genes		18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4	9 interacting genes: CDK5 CSNK2A1 CSNK2A2 DLGAP4 KLHL6 PPP1CA PRKACA ROBO2 TFCP2
Entrez ID		6092	84152
HPRD ID		11895	05097
Ensembl ID		ENSG00000185008	ENSG00000131771
Uniprot IDs		A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4	B3KVQ9 Q9UD71
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA	Not available
GO Terms Enriched among Interactors		Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis	Protein Kinase CK2 Complex Regulation Of Macroautophagy Neuromuscular Junction Protein Serine Kinase Activity Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Protein Catabolic Process Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling PcG Protein Complex Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Macromolecule Catabolic Process Regulation Of Protein Export From Nucleus Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynapse Hsp90 Protein Binding Kinase Activity Central Nervous System Neuron Development Protein Catabolic Process Double-strand Break Repair Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Rhythmic Process Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synapse Organization Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Establishment Of Protein Localization Anatomical Structure Formation Involved In Morphogenesis Regulation Of Chromosome Separation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Regulation Of Neurotransmitter Secretion Cerebral Cortex Development Negative Regulation Of Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Apoptotic Process Regulation Of Apoptotic Signaling Pathway