TXNL1 and SH3BP4

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		TXNL1	SH3BP4
Description		thioredoxin like 1	SH3 domain binding protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity	GDP-dissociation Inhibitor Activity Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process		Endocytosis Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways		RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Diverticular disease ( 30177863) General risk tolerance (MTAG) ( 30643258) Morning person ( 30696823) Number of sexual partners ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Obstetric antiphospholipid syndrome ( 28424481) Orofacial clefts ( 22419666) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: CDC42 CEBPA HSPB1 PSMC3 SH3BP4 SUMO4	23 interacting genes: CCT3 CEP78 CFTR CIMIP6 CIZ1 DNAJA4 EPS15 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 SNCA TCP1 TTC1 TXNL1 YWHAG ZBTB37
Entrez ID		9352	23677
HPRD ID		04335	09285
Ensembl ID		ENSG00000091164	ENSG00000130147
Uniprot IDs		O43396 V9HW51	Q9P0V3
PDB IDs		1GH2 1WWY 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O
Enriched GO Terms of Interacting Partners?		Host-mediated Perturbation Of Viral Process Macrophage Differentiation GBD Domain Binding Storage Vacuole Identical Protein Binding Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase C Signaling Proteasome Complex Endothelin Receptor Signaling Pathway Involved In Heart Process Myeloid Leukocyte Differentiation CHOP-C/EBP Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase C Inhibitor Activity Amino Acid Import Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway White Fat Cell Proliferation SUMO Ligase Complex Transport Along Microtubule Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Intracellular Signal Transduction Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Proteolysis Response To Phenylpropanoid RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Protein Kinase C Signaling Proteasome-activating Activity Establishment Of Golgi Localization Spindle Fat Cell Proliferation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Myeloid Cell Differentiation Anterograde Axonal Protein Transport Leading Edge Membrane Thioesterase Binding Neuron Fate Determination	Protein Folding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone Cytosol Protein Folding Chaperone Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Heat Shock Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Receptor Recycling Negative Regulation Of Microtubule Polymerization Protein-folding Chaperone Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Refolding Regulation Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Steroid Hormone Receptor Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Phosphoprotein Binding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Binding Of Sperm To Zona Pellucida Sperm-egg Recognition H4/H2A Histone Acetyltransferase Complex ATP Hydrolysis Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Tau Protein Binding Maintenance Of Protein Localization In Organelle Regulation Of Protein Stability Protein Sequestering Activity Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process
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