TXNL1 and SH3BP4

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		TXNL1	SH3BP4
Gene Name		thioredoxin-like 1	SH3-domain binding protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Coated Pit Clathrin-coated Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Disulfide Oxidoreductase Activity Disulfide Oxidoreductase Activity	GDP-dissociation Inhibitor Activity Protein Binding Ras GTPase Binding Identical Protein Binding
	Biological Process	Glycerol Ether Metabolic Process Cell Redox Homeostasis Oxidation-reduction Process	Endocytosis Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Negative Regulation Of Cell Growth Negative Regulation Of TOR Signaling Negative Regulation Of GTPase Activity Amino Acid Import Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Orofacial clefts ( 22419666)
Protein-Protein Interactions		4 interactors: PSMC3 PSMD14 SH3BP4 SUMO4	21 interactors: C2orf73 CCT3 CEP78 CIZ1 DNAJA4 FKBP4 GAPDHS GKAP1 HSPA5 MPHOSPH8 MRGBP NFU1 PLEKHA1 PRR14 PSMA1 TCP1 TTC1 TXNL1 YWHAE YWHAG ZBTB37
Entrez ID		9352	23677
HPRD ID		04335	09285
Ensembl ID			ENSG00000130147
Uniprot IDs		O43396	Q9P0V3
PDB IDs		1GH2 1WWY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Catalytic Activity Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Protein Folding Toxin Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Heat G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Binding Of Sperm To Zona Pellucida Protein Localization Substantia Nigra Development Response To Temperature Stimulus Sperm-egg Recognition Steroid Hormone Receptor Complex Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Neural Nucleus Development 'de Novo' Posttranslational Protein Folding Positive Regulation Of Mitochondrion Organization 'de Novo' Protein Folding Cell-cell Recognition Cellular Response To Heat Negative Regulation Of Peptidyl-serine Dephosphorylation Cerebellum Structural Organization Regulation Of Heart Rate By Hormone Mitotic Cell Cycle Process Midbrain Development Positive Regulation Of DNA-dependent DNA Replication Initiation Mitotic Cell Cycle Regulation Of Mitochondrion Organization Cell Recognition Single Fertilization Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of DNA-dependent DNA Replication Initiation Cellular Response To Stress Maintenance Of Protein Location In Cell Regulation Of Cell Death
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