TRIP11 and THRA

Number of citations: 48 (PubMedID 9256431)
Data Source: BioGRID (pull down)

		TRIP11	THRA
Name		thyroid hormone receptor interactor 11	thyroid hormone receptor alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Small GTPase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Thyroid Hormone Binding General Transcription Initiation Factor Binding
	Biological Process	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of DNA-templated Transcription Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Bone Development Protein Transmembrane Transport Golgi Ribbon Formation Vesicle Tethering To Golgi	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Receptor Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription Initiation
Pathways		Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Nuclear Receptor transcription pathway
Drugs		None	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases		Achodrogenesis type IA	None
GWAS		Appendicular lean mass ( 33097823 ) Body size at age 10 ( 32376654 ) FEV1 ( 30804560 ) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883 ) Height ( 18391951 31562340 28552196 18391950 25429064 25282103 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) LDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Lung function (FEV1) ( 26635082 ) Lung function (FVC) ( 26635082 30804560 ) Major depressive disorder ( 34099189 ) Major depressive disorder x sex interaction ( 34099189 ) Refractive error ( 32231278 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412 )	Asthma ( 31619474 ) Bipolar disorder ( 31043756 ) Chronic obstructive pulmonary disease ( 30804561 ) Pancreatic ductal adenocarcinoma ( 30541042 ) White blood cell count ( 21738480 )
Novel Interactors		4 novel interactors: ASB2 EPS8 GPR65 SERPINA4	None recorded
Interacting Genes		9 interacting genes: ARNT ATXN1L DSCAM MYBPC2 PSMC5 RB1 SNCA THRA WDR37	68 interacting genes: AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		9321	7067
HPRD ID		05143	07185
Ensembl ID		ENSG00000100815	ENSG00000126351
Uniprot IDs		Q15643	P10827 Q6FH41
PDB IDs		Not available	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX 7QDT 8RQO
GO Terms Enriched among Interactors		Regulation Of Protein-containing Complex Assembly General Transcription Initiation Factor Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Growth Cone Dendritic Cell Migration Negative Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Inclusion Body TBP-class Protein Binding Locomotory Behavior Phosphoprotein Binding Regulation Of Phosphorus Metabolic Process Nuclear Receptor Activity Social Behavior Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Interleukin-22 Production Regulation Of Actin Filament Organization Skeletal Muscle Cell Differentiation Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Phosphate Metabolic Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Organelle Organization Nuclear Proteasome Complex Striated Muscle Cell Differentiation Erythrocyte Differentiation Transcription By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Adult Locomotory Behavior Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Negative Regulation Of DNA-templated Transcription Thyrotropin-releasing Hormone Receptor Binding Negative Regulation Of RNA Biosynthetic Process Chromatin Lock Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Nuclear Receptor Binding Regulation Of Primary Metabolic Process Nuclear Retinoic Acid Receptor Binding Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Estrogen Receptor Binding Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Chromatin Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway DNA-templated Transcription Transcription Coactivator Activity Intracellular Signal Transduction Transcription Coregulator Activity Transcription Regulator Complex