TRIP11 and GPR65

Data Source: HiPPIP (Novel)

		TRIP11	GPR65
Name		thyroid hormone receptor interactor 11	G protein-coupled receptor 65
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Cytoskeleton Cilium Membrane Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Small GTPase Binding	G Protein-coupled Receptor Activity
	Biological Process	Ventricular Septum Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Transcription By RNA Polymerase II Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Positive Regulation Of DNA-templated Transcription Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Bone Development Protein Transmembrane Transport Golgi Ribbon Formation Vesicle Tethering To Golgi	Apoptotic Process Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Acidic PH Positive Regulation Of Interleukin-22 Production Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Stress Fiber Assembly Cellular Response To Acidic PH
Pathways		Intraflagellar transport Intra-Golgi traffic Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events
Diseases		Achodrogenesis type IA	None
GWAS		Appendicular lean mass ( 33097823 ) Body size at age 10 ( 32376654 ) FEV1 ( 30804560 ) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883 ) Height ( 18391951 31562340 28552196 18391950 25429064 25282103 20881960 ) Hip circumference adjusted for BMI ( 34021172 ) LDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Lung function (FEV1) ( 26635082 ) Lung function (FVC) ( 26635082 30804560 ) Major depressive disorder ( 34099189 ) Major depressive disorder x sex interaction ( 34099189 ) Refractive error ( 32231278 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412 )	Ankylosing spondylitis ( 23749187 ) California verbal learning test score ( 31596458 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Crohn's disease ( 21102463 28067908 ) Degraded stimulus continuous performance test score ( 31596458 ) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135 ) Eosinophil percentage of white cells ( 32888494 ) Food antigen IgG levels ( 24962563 ) Inflammatory bowel disease ( 23128233 28067908 ) Multiple sclerosis ( 21833088 ) Parkinson's disease ( 32201043 ) Takayasu arteritis ( 25604533 )
Interacting Genes		9 interacting genes: ARNT ATXN1L DSCAM MYBPC2 PSMC5 RB1 SNCA THRA WDR37	None recorded
Entrez ID		9321	8477
HPRD ID		05143	07057
Ensembl ID		ENSG00000100815	ENSG00000140030
Uniprot IDs		Q15643	B5B0C2 Q8IYL9
PDB IDs		Not available	9BHL
GO Terms Enriched among Interactors		Regulation Of Protein-containing Complex Assembly General Transcription Initiation Factor Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Growth Cone Dendritic Cell Migration Negative Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Inclusion Body TBP-class Protein Binding Locomotory Behavior Phosphoprotein Binding Regulation Of Phosphorus Metabolic Process Nuclear Receptor Activity Social Behavior Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Interleukin-22 Production Regulation Of Actin Filament Organization Skeletal Muscle Cell Differentiation Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Phosphate Metabolic Process Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Organelle Organization Nuclear Proteasome Complex Striated Muscle Cell Differentiation Erythrocyte Differentiation Transcription By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Adult Locomotory Behavior Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Negative Regulation Of DNA-templated Transcription Thyrotropin-releasing Hormone Receptor Binding Negative Regulation Of RNA Biosynthetic Process Chromatin Lock Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity	Futile Creatine Cycle Phosphocreatine Biosynthetic Process Creatine Kinase Activity Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Vesicle Tethering To Golgi Golgi Ribbon Formation Transferase Activity, Transferring Phosphorus-containing Groups Acrosomal Membrane Vesicle Tethering Ventricular Septum Development Inner Ear Receptor Cell Stereocilium Organization Substantia Nigra Development Cardiac Septum Development Cis-Golgi Network Neural Nucleus Development Chondrocyte Differentiation