PPP3R2 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PPP3R2	PTPN12
Description		protein phosphatase 3 regulatory subunit B, beta	protein tyrosine phosphatase non-receptor type 12
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Sperm Flagellum Sperm Midpiece Sperm Mitochondrial Sheath	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding
	Biological Process	Penetration Of Zona Pellucida Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs		Cyclosporine Voclosporin	Tiludronic acid
Diseases
GWAS			A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte count ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: APC AURKA BUB1 CCND1 CD14 DLC1 DYNLL1 FBXW7 KRT34 MLH3 MSH2 PDGFRL PTPN12 PTPRJ RAB32 SMAD4 TBC1D10C TFCP2	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		5535	5782
HPRD ID		10164	02513
Ensembl ID		ENSG00000188386	ENSG00000127947
Uniprot IDs		Q96LZ3	B4E105 Q05209
PDB IDs			5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Centromeric DNA Binding Kinetochore Negative Regulation Of Mitotic Cell Cycle Gamma-catenin Binding Mismatched DNA Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway DNA Damage Response Ruffle Membrane ATP-dependent DNA Damage Sensor Activity Negative Regulation Of Cell Cycle Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Supramolecular Fiber Organization Protein-containing Complex Binding Negative Regulation Of Phosphate Metabolic Process Response To Stress Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Signaling Negative Regulation Of Phosphorylation Mitotic Cell Cycle Phase Transition Liver Regeneration Response To UV Response To X-ray Cell Cycle Phase Transition Regeneration Organelle Organization Chromosome Organization Mismatch Repair Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway	Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Kinase Activity Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Signal Transduction Phosphorylation Receptor Complex Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Phosphate Metabolic Process Perinuclear Region Of Cytoplasm Response To Growth Factor Positive Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Animal Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion Insulin Receptor Substrate Binding Positive Regulation Of Protein Phosphorylation Anchoring Junction Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Regulation Of Cell Motility Positive Regulation Of Developmental Process
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