PPP3R2 and TBC1D10C

Number of citations of the paper that reports this interaction (PubMedID 17230191)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP3R2	TBC1D10C
Description		protein phosphatase 3 regulatory subunit B, beta	TBC1 domain family member 10C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Sperm Flagellum Sperm Midpiece Sperm Mitochondrial Sheath	Cytosol Plasma Membrane Membrane Filopodium Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Metal Ion Binding	GTPase Activator Activity Protein Binding
	Biological Process	Penetration Of Zona Pellucida Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Calcineurin-NFAT Signaling Cascade B Cell Activation Retrograde Transport, Endosome To Golgi Negative Regulation Of B Cell Activation ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cilium Assembly
Pathways			Neutrophil degranulation TBC/RABGAPs
Drugs		Cyclosporine Voclosporin
Diseases
GWAS			Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		18 interacting genes: APC AURKA BUB1 CCND1 CD14 DLC1 DYNLL1 FBXW7 KRT34 MLH3 MSH2 PDGFRL PTPN12 PTPRJ RAB32 SMAD4 TBC1D10C TFCP2	7 interacting genes: APP HOXA1 KLHL12 KRTAP13-1 KRTAP5-9 NOTCH2NLA PPP3R2
Entrez ID		5535	374403
HPRD ID		10164	13330
Ensembl ID		ENSG00000188386	ENSG00000175463
Uniprot IDs		Q96LZ3	Q8IV04
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Centromeric DNA Binding Kinetochore Negative Regulation Of Mitotic Cell Cycle Gamma-catenin Binding Mismatched DNA Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway DNA Damage Response Ruffle Membrane ATP-dependent DNA Damage Sensor Activity Negative Regulation Of Cell Cycle Process Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Supramolecular Fiber Organization Protein-containing Complex Binding Negative Regulation Of Phosphate Metabolic Process Response To Stress Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Negative Regulation Of Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Signaling Negative Regulation Of Phosphorylation Mitotic Cell Cycle Phase Transition Liver Regeneration Response To UV Response To X-ray Cell Cycle Phase Transition Regeneration Organelle Organization Chromosome Organization Mismatch Repair Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Visual Behavior Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Calcium-mediated Signaling Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Calcium-mediated Signaling Lipoprotein Particle Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Intermediate Filament Sperm Mitochondrial Sheath Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Axon Choice Point Recognition Identical Protein Binding Heparan Sulfate Binding Signaling Receptor Activator Activity Embryonic Neurocranium Morphogenesis
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