ADGRG1 and CCR9

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADGRG1	CCR9
Description		adhesion G protein-coupled receptor G1	C-C motif chemokine receptor 9
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Glial Limiting End-foot	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Collagen Binding Heparin Binding Extracellular Matrix Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Angiogenesis Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Cell-cell Signaling Nervous System Development Brain Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Cell Migration Cerebral Cortex Regionalization Cerebral Cortex Radial Glia-guided Migration Layer Formation In Cerebral Cortex Cell Differentiation Positive Regulation Of Rho Protein Signal Transduction Tube Development Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Neural Precursor Cell Proliferation Hematopoietic Stem Cell Homeostasis Seminiferous Tubule Development Regulation Of Platelet Aggregation Negative Regulation Of Ferroptosis Rho-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Neuron Migration	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS			Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		3 interacting genes: ADRB2 CCR9 DRD2	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		9289	10803
HPRD ID		06824	09200
Ensembl ID		ENSG00000205336	ENSG00000173585
Uniprot IDs		A0A024R6U7 A0A0S2Z517 B3KQN7 B3KQV4 B4DM06 Q9Y653	B2R734 P51686
PDB IDs		7SF8	5LWE
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction Potassium Channel Regulator Activity Temperature Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Negative Regulation Of Blood Pressure Regulation Of Multicellular Organism Growth Regulation Of Sodium Ion Transport G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Muscle Contraction Beta-adrenergic Receptor Activity Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Beta2-adrenergic Receptor Activity G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Muscle System Process Norepinephrine Binding Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Response To Psychosocial Stress Regulation Of Developmental Growth Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Autophagosome Maturation Regulation Of Metal Ion Transport Heat Generation Regulation Of Synapse Structural Plasticity	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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