WBP2 and ANAPC1

Number of citations of the paper that reports this interaction (PubMedID 27578003)
0

Data Source:
BioGRID (two hybrid)

		WBP2	ANAPC1
Description		WW domain binding protein 2	anaphase promoting complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding	Molecular Adaptor Activity
	Biological Process	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Establishment Of Protein Localization To Chromatin Cellular Response To Estrogen Stimulus	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Platelet count ( 32888494) Red blood cell count ( 32888494) White matter hyperintensities ( 32358547)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Corneal endothelial cell density ( 30894546) Corneal hysteresis ( 32716492 31246245 30894546) Corneal resistance factor ( 32716492 31246245 30894546) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Intraocular pressure ( 30054594 29785010) Obesity-related traits ( 23251661)
Interacting Genes		54 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 BAG3 CCT7 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HUWE1 ITCH KRT18 KRT8 KRT9 LGALS8 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 RUNX1 SDHA SEPTIN3 SMAD5 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE2E3 UBE3A UBQLN1 UIMC1 WWC3 WWP1 WWP2 WWTR1 YAP1	12 interacting genes: CDC20 CDC27 FBXO5 FZR1 HRAS ID2 MDC1 PTTG1 SUMO2 UBC UBE2S WBP2
Entrez ID		23558	64682
HPRD ID		06097	09769
Ensembl ID		ENSG00000132471	ENSG00000153107
Uniprot IDs		A6NG10 Q969T9	Q9H1A4
PDB IDs			4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 5LGG 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		COPI Vesicle Coat COPI-coated Vesicle Membrane Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cytosol Protein Ubiquitination Protein Modification By Small Protein Conjugation COPI-coated Vesicle Intra-Golgi Vesicle-mediated Transport Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Polyubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Transport Vesicle Protein Monoubiquitination Nucleoplasm Protein K48-linked Ubiquitination Structural Molecule Activity Membrane Coat Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Proteolysis Cytoplasm Potassium Channel Inhibitor Activity Protein K63-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Nephron Tubule Epithelial Cell Differentiation Extracellular Exosome Catabolic Process Protein Tag Activity Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Ubiquitin Protein Ligase Activity Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Proteasomal Protein Catabolic Process Nuclear Receptor-mediated Signaling Pathway Ubiquitin Binding Protein Catabolic Process Golgi Vesicle Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Histone Ubiquitin Ligase Activity Intracellular Protein Transport Negative Regulation Of Potassium Ion Transmembrane Transport Vesicle-mediated Transport Cytoplasmic Vesicle Cardiac Muscle Tissue Regeneration Intracellular Protein Localization Negative Regulation Of Cation Transmembrane Transport	Anaphase-promoting Complex Binding Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Cell Division Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Meiotic Nuclear Division Regulation Of Cell Cycle Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Regulation Of Reproductive Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Protein Tag Activity Regulation Of Sister Chromatid Segregation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Negative Regulation Of Cellular Senescence Mitotic Cell Cycle Phase Transition Nucleus
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