PIWIL1 and DICER1

Number of citations of the paper that reports this interaction (PubMedID 14749716)
31

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		PIWIL1	DICER1
Description		piwi like RNA-mediated gene silencing 1	dicer 1, ribonuclease III
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GO Annotations	Cellular Component	Nucleus Cytoplasm Chromatoid Body P Granule Dense Body	Nucleus Cytoplasm Cytosol RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding PiRNA Binding Metal Ion Binding MRNA Cap Binding Complex Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Helicase Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Regulatory RNA Binding Pre-miRNA Binding
	Biological Process	Regulation Of Translation Spermatogenesis Spermatid Development Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Sperm DNA Condensation Meiotic Cell Cycle Primary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation RNA Processing MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Schwann Cell Differentiation TRNA Decay Post-transcriptional Gene Silencing Nerve Development SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production MiRNA Processing Neuron Projection Morphogenesis Regulation Of Multicellular Organismal Process RISC Complex Assembly Global Gene Silencing By MRNA Cleavage
Pathways		PIWI-interacting RNA (piRNA) biogenesis	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis
Drugs
Diseases
GWAS		Menopause (age at onset) ( 26414677) Triglyceride levels in HIV infection ( 33109212)	Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)
Interacting Genes		3 interacting genes: DICER1 RNF10 TRIM54	12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25
Entrez ID		9271	23405
HPRD ID		10409	05875
Ensembl ID		ENSG00000125207	ENSG00000100697
Uniprot IDs		Q96J94	H0YJZ6 Q9UPY3
PDB IDs		2L5C 2L5D 3O3I 3O6E 3O7V 6PI7	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM 7XW2 7XW3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Regulatory RNA Binding Negative Regulation Of Nervous System Development Peripheral Nervous System Myelin Formation Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Negative Regulation Of Cell Development Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Ubiquitin Protein Ligase Activity Regulation Of Neurogenesis RISC-loading Complex SiRNA Processing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Regulation Of Nervous System Development SiRNA Binding RISC Complex Assembly TRNA Decay Apoptotic DNA Fragmentation Pre-miRNA Processing Myelin Assembly Regulation Of System Process MiRNA Metabolic Process Negative Regulation Of Cell Differentiation DNA Catabolic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway MiRNA Processing Regulation Of Cell Development RNA Endonuclease Activity Positive Regulation Of Glial Cell Differentiation Regulation Of Microtubule Depolymerization Microtubule Associated Complex Negative Regulation Of Microtubule Polymerization Or Depolymerization Nerve Development Negative Regulation Of Developmental Process	Double-stranded RNA Binding Regulatory NcRNA-mediated Gene Silencing RISC-loading Complex RISC Complex Assembly RNA Endonuclease Activity Pre-miRNA Processing RNA Binding Regulation Of Translation Negative Regulation Of Gene Expression MiRNA Processing PiRNA Binding SiRNA Processing Post-transcriptional Gene Silencing Single-stranded RNA Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding Antiviral Innate Immune Response PiRNA Processing P Granule RISC Complex Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation RNA Processing MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Secondary PiRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA Binding Positive Regulation Of MRNA Metabolic Process Transposable Element Silencing PiRNA-mediated Gene Silencing By MRNA Destabilization SiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Dense Body Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Constitutive Heterochromatin Formation Protein-RNA Complex Assembly Negative Regulation Of Metabolic Process Regulation Of RNA Stability Pre-miRNA Binding Endonuclease Activity Cytoplasm Regulation Of Protein Metabolic Process
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