PIWIL1

Name	piwi like RNA-mediated gene silencing 1
Structure
Interactors	3 interactors: DICER1 RNF10 TRIM54
GO Annotations	Cellular Component	Nucleus Cytoplasm Chromatoid Body P Granule Dense Body
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding PiRNA Binding Metal Ion Binding MRNA Cap Binding Complex Binding
	Biological Process	Regulation Of Translation Spermatogenesis Spermatid Development Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Sperm DNA Condensation Meiotic Cell Cycle Primary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation
Pathways	PIWI-interacting RNA (piRNA) biogenesis
GWAS	Menopause (age at onset) ( 26414677 ) Triglyceride levels in HIV infection ( 33109212 )
Entrez ID	9271
HPRD ID	10409
Ensembl ID	ENSG00000125207
Uniprot IDs	Q96J94
PDB IDs	2L5C 2L5D 3O3I 3O6E 3O7V 6PI7
GO Terms Enriched among Interactors ?	Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Regulatory RNA Binding Negative Regulation Of Nervous System Development Peripheral Nervous System Myelin Formation Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Negative Regulation Of Cell Development Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Ubiquitin Protein Ligase Activity Regulation Of Neurogenesis RISC-loading Complex SiRNA Processing Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Regulation Of Nervous System Development SiRNA Binding RISC Complex Assembly TRNA Decay Apoptotic DNA Fragmentation Pre-miRNA Processing Myelin Assembly Regulation Of System Process MiRNA Metabolic Process Negative Regulation Of Cell Differentiation DNA Catabolic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway MiRNA Processing Regulation Of Cell Development RNA Endonuclease Activity Positive Regulation Of Glial Cell Differentiation Regulation Of Microtubule Depolymerization Microtubule Associated Complex Negative Regulation Of Microtubule Polymerization Or Depolymerization Nerve Development Negative Regulation Of Developmental Process