CD8B and CD8A

Number of citations: 35 (PubMedID 3145195)
Data Source: BioGRID (imaging technique), HPRD (in vivo, in vitro)

		CD8B	CD8A
Name		CD8 subunit beta	CD8 subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Early Endosome Membrane T Cell Receptor Complex Receptor Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane T Cell Receptor Complex Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Binding	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Immune Response T Cell Receptor Signaling Pathway	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation T Cell Receptor Signaling Pathway
Pathways		Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases		None	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Progressive supranuclear palsy ( 21685912 )	Blood protein levels ( 30072576 )
Novel Interactors		1 novel interactors: MRPS5	2 novel interactors: GGCX MRPS5
Interacting Genes		3 interacting genes: CD3D CD8A ST3GAL4	17 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 PTPRC SREK1 SRSF1
Entrez ID		926	925
HPRD ID		01725	01737
Ensembl ID		ENSG00000172116	ENSG00000153563
Uniprot IDs		P10966 Q53QL8	P01732 Q6ZVS2 Q8TAW8
PDB IDs		Not available	1AKJ 1CD8 1Q69 2HP4 3QZW 7UMG 7UVF 8EW6
GO Terms Enriched among Interactors		T Cell Receptor Complex T Cell Receptor Signaling Pathway Cytotoxic T Cell Differentiation Antigen Receptor-mediated Signaling Pathway Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Adaptive Immune Response Alpha-beta T Cell Receptor Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation MHC Class I Protein Complex Binding Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Positive T Cell Selection Positive Thymic T Cell Selection Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Activation Of Immune Response Regulation Of Immune System Process Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling Sialylation Keratan Sulfate Proteoglycan Biosynthetic Process Keratan Sulfate Proteoglycan Metabolic Process Lymphocyte Activation MHC Class I Protein Binding Sialyltransferase Activity Thymic T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Oligosaccharide Biosynthetic Process Leukocyte Activation Positive Regulation Of Blood Coagulation T Cell Selection Viral Protein Processing Mitochondrial Small Ribosomal Subunit Positive Regulation Of Coagulation Positive Regulation Of Immune Response Cell Activation Plasma Membrane Raft T Cell Mediated Immunity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Protein O-linked Glycosylation Via N-acetyl-galactosamine Oligosaccharide Metabolic Process Coreceptor Activity Proteoglycan Biosynthetic Process Glycolipid Biosynthetic Process Golgi Cisterna Membrane Positive Regulation Of Wound Healing	MHC Class I Protein Complex Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I ER To Golgi Transport Vesicle Membrane Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Adaptive Immune Response Regulation Of T Cell Mediated Immunity Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains External Side Of Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Lumenal Side Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Lymphocyte Activation Regulation Of Immune System Process T Cell Activation Antigen Processing And Presentation Recycling Endosome Membrane Regulation Of Lymphocyte Mediated Immunity TAP Binding Early Endosome Membrane T Cell Receptor Signaling Pathway Negative Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Immune System Process Regulation Of T Cell Activation CD8 Receptor Binding Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Immune Effector Process Cell Activation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway