CD8B and CD3D

Number of citations of the paper that reports this interaction (PubMedID 12215456)
0

Data Source:
HPRD (in vivo)

		CD8B	CD3D
Description		CD8 subunit beta	CD3 delta subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Early Endosome Membrane T Cell Receptor Complex Receptor Complex	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Immune Response T Cell Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
Pathways		Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Muromonab Blinatumomab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Progressive supranuclear palsy ( 21685912)	Pulse pressure ( 27841878)
Interacting Genes		3 interacting genes: CD3D CD8A ST3GAL4	12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB
Entrez ID		926	915
HPRD ID		01725	01730
Ensembl ID		ENSG00000172116	ENSG00000167286
Uniprot IDs		P10966 Q53QL8	B0YIY4 P04234
PDB IDs			1XIW 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		T Cell Receptor Complex T Cell Receptor Signaling Pathway Cytotoxic T Cell Differentiation Antigen Receptor-mediated Signaling Pathway Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Adaptive Immune Response Alpha-beta T Cell Receptor Complex Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Activation MHC Class I Protein Complex Binding Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Positive T Cell Selection Positive Thymic T Cell Selection Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Activation Of Immune Response Regulation Of Immune System Process Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling Sialylation Keratan Sulfate Proteoglycan Biosynthetic Process Keratan Sulfate Proteoglycan Metabolic Process Lymphocyte Activation MHC Class I Protein Binding Sialyltransferase Activity Thymic T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Oligosaccharide Biosynthetic Process Leukocyte Activation Positive Regulation Of Blood Coagulation T Cell Selection Viral Protein Processing Mitochondrial Small Ribosomal Subunit Positive Regulation Of Coagulation Positive Regulation Of Immune Response Cell Activation Plasma Membrane Raft T Cell Mediated Immunity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Protein O-linked Glycosylation Via N-acetyl-galactosamine Oligosaccharide Metabolic Process Coreceptor Activity Proteoglycan Biosynthetic Process Glycolipid Biosynthetic Process Golgi Cisterna Membrane Positive Regulation Of Wound Healing	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Tumor Cell Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target T Cell Mediated Immunity Immune Response-activating Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Lymphocyte Activation Immune Response To Tumor Cell Membrane Leukocyte Activation Positive Thymic T Cell Selection T Cell Receptor Binding Alpha-beta T Cell Activation Positive T Cell Selection Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Immune Response Lymphocyte Mediated Immunity MHC Class I Protein Binding T Cell Mediated Cytotoxicity Immune System Process Thymic T Cell Selection Protein-containing Complex Assembly Endoplasmic Reticulum Quality Control Compartment Leukocyte Mediated Immunity Protein-containing Complex Organization T Cell Selection Protein Targeting To ER Clathrin-dependent Endocytosis Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Immune Response Synaptic Vesicle Endocytosis Positive Regulation Of Immune System Process Presynaptic Endocytosis Transmembrane Signaling Receptor Activity Plasma Membrane Protein Complex Oligomerization
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