TMEM222 and RNASEK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM222	RNASEK
Description		transmembrane protein 222	ribonuclease K
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Dendrite Cell Projection	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex
	Molecular Function	Protein Binding	Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity
	Biological Process		Monoatomic Ion Transport Endocytosis Receptor-mediated Endocytosis Vacuolar Acidification Lysosomal Lumen Acidification Receptor-mediated Endocytosis Of Virus By Host Cell Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 31219225)
Interacting Genes		40 interacting genes: ABHD16A AQP6 BIK BSCL2 CD79A CLDN5 CLRN1 COMT CRB3 CREB3 CREB3L1 EBP ELOVL4 ERG28 ERGIC3 EVI2B FAM174A FAM209A HIBADH HSD17B13 KIR2DL3 LMNA LRRC59 NCR3LG1 PEX12 PRSS23 PTGES RETREG3 RNASEK RUNX1 SLC10A1 SLC10A2 SLC10A6 SSMEM1 STX1A TMEM14B TMEM35A TMPRSS2 TMX2 ZDHHC15	26 interacting genes: ARV1 ATP13A1 BNIP3 CYSLTR2 FIS1 FXYD6 GIMAP5 HMOX2 LRCH4 NINJ2 RTP2 SEC22A SERF1A SERF1B SERP2 SMAGP STX8 TAAR1 TIMM23 TMEM203 TMEM222 TMEM60 TREX1 VAPB VTI1B ZDHHC21
Entrez ID		84065	440400
HPRD ID		13167	17568
Ensembl ID		ENSG00000186501	ENSG00000219200
Uniprot IDs		Q9H0R3	A0A0C4DH89 Q6P5S7
PDB IDs			6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Membrane Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Membrane Bile Acid And Bile Salt Transport Endoplasmic Reticulum Protein Binding Positive Regulation Of Granulocyte Differentiation	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Membrane Organization Chloride Channel Inhibitor Activity Establishment Of Protein Localization Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Calcium Ion Homeostasis Cellular Localization Organelle Localization By Membrane Tethering Protein Targeting Calcium Ion Homeostasis Membrane Docking Positive Regulation Of Mitochondrial Fission Intracellular Chemical Homeostasis Regulation Of Mitochondrial Fission Mitochondrion Autophagosome Adaptor Activity Amyloid Fibril Formation Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Protein Targeting To Mitochondrion Cysteinyl Leukotriene Receptor Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Regulation Of Plasma Membrane Sterol Distribution G Protein-coupled Amine Receptor Activity Membrane Fusion Macroautophagy
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