DLGAP2 and PINX1

		DLGAP2	PINX1
Description		DLG associated protein 2	PIN2 (TERF1) interacting telomerase inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Neurofilament Plasma Membrane Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Specialization	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Mitochondrion Spindle
	Molecular Function	Protein Binding Molecular Adaptor Activity	Nucleic Acid Binding Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Neuron-neuron Synaptic Transmission Signaling Modulation Of Chemical Synaptic Transmission	Telomere Maintenance Via Telomerase Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Protein Localization To Nucleolus
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Daytime nap ( 33568662) End-stage renal disease ( 29885931) Eye morphology ( 29921221) Femur bone mineral density x serum urate levels interaction ( 34046847) Lung cancer ( 28604730) Menarche (age at onset) ( 23599027) Neuritic plaque ( 31497858) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 30306274) Stroke ( 32693751) Tau burden ( 33426524) Triglycerides ( 24886709) White matter microstructure in first episode schizophrenia (right posterior cingulate cortex) ( 28924203)	A body shape index ( 34021172) Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte count ( 27863252 32888494) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 30275531 24097068 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		18 interacting genes: ABI2 ADRB1 CYSRT1 DGCR6 DLG2 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 MAGI2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2 TSPOAP1 UBASH3B	17 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TFRC TLK1 TNPO2 TP63 UBL5
Entrez ID		9228	54984
HPRD ID		09258	05934
Ensembl ID		ENSG00000198010	ENSG00000254093
Uniprot IDs		A0A1B0GTN4	Q96BK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Vocalization Behavior Ionotropic Glutamate Receptor Binding Receptor Clustering Synapse Social Behavior Dendritic Spine Scaffold Protein Binding Beta-1 Adrenergic Receptor Binding Synaptic Receptor Adaptor Activity AMPA Glutamate Receptor Clustering Modulation Of Chemical Synaptic Transmission Modulation Of Excitatory Postsynaptic Potential Learning Neuron Projection Cell Projection Synaptic Signaling Neuron Spine Photoreceptor Inner Segment Juxtaparanode Region Of Axon Regulation Of Membrane Potential Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Postsynaptic Membrane Dendritic Spine Morphogenesis Kinase Binding Postsynaptic Density Membrane Learning Or Memory Calyx Of Held Response To Potassium Ion SH3 Domain Binding Cytoskeletal Anchor Activity Regulation Of System Process Regulation Of Nervous System Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Membrane Chemical Synaptic Transmission Cognition Regulation Of The Force Of Heart Contraction Regulation Of Long-term Neuronal Synaptic Plasticity Cell-cell Signaling Trans-synaptic Signaling Signaling Excitatory Synapse Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Adult Behavior Cell Communication	Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Nuclear Envelope Lumen Nuclear Telomere Cap Complex Telomerase Activity Regulation Of Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Response To Manganese Ion Protein-folding Chaperone Binding Protein Homodimerization Activity Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor Response To Leukemia Inhibitory Factor Notch Signaling Pathway RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of DNA Replication Negative Regulation Of Cellular Senescence Telomeric DNA Binding Telomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Response To Metal Ion Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Establishment Of Protein Localization To Telomere Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomere Maintenance Via Telomere Lengthening TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Ectoderm And Mesoderm Interaction Epidermal Cell Division Determination Of Ventral Identity Positive Regulation Of Stem Cell Proliferation Regulation Of Cellular Senescence Acetylcholine Receptor Activator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import
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