NPR1 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		NPR1	ATF7IP
Description		natriuretic peptide receptor 1	activating transcription factor 7 interacting protein
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex ANPR-A Receptor Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Physiological factors	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs		Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases
GWAS		Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		4881	55729
HPRD ID		00165	09811
Ensembl ID		ENSG00000169418	ENSG00000171681
Uniprot IDs		A0A140VJE6 P16066	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		8TG9 8TGA 9BCL 9BCN 9BCO 9BCP 9BCQ 9BCS 9BCV	2RPQ
Enriched GO Terms of Interacting Partners?		Hormone Receptor Binding CGMP-mediated Signaling Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Cyclic Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Vasodilation Vascular Process In Circulatory System Positive Regulation Of CGMP-mediated Signaling Circulatory System Process Cell Growth Involved In Cardiac Muscle Cell Development Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Cardiac Conduction System Development Bone Growth Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Protein-containing Complex Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Negative Regulation Of Blood Pressure Organ Growth Ribonucleotide Metabolic Process Intracellular Signaling Cassette Ribose Phosphate Metabolic Process Cardiac Muscle Tissue Development Purine Nucleotide Metabolic Process Developmental Growth Negative Regulation Of Collecting Lymphatic Vessel Constriction Signaling Receptor Binding Diuretic Hormone Activity Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Neuropeptide Signaling Pathway Neuropeptide Receptor Binding Response To 3-methylcholanthrene Purine-containing Compound Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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