NPR1 and PRKG1

Number of citations of the paper that reports this interaction (PMID 12855709)
5

Data Source:
HPRD (in vitro, two hybrid)

		NPR1	PRKG1
Gene Name		natriuretic peptide receptor 1	protein kinase, cGMP-dependent, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways			Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs		Nitroprusside Nitroglycerin Isosorbide Dinitrate Amyl Nitrite Erythrityl Tetranitrate Nesiritide
Diseases
GWAS			Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ATF7IP NPPA NPPB NPPC PRKG1	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		4881	5592
HPRD ID		00165	08910
Ensembl ID		ENSG00000169418	ENSG00000185532
Uniprot IDs		P16066	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Size Regulation Of Tube Size Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Circulation Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Cell Growth Regulation Of Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Blood Pressure Negative Regulation Of Oocyte Maturation Organophosphate Metabolic Process Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Muscle System Process Growth Plate Cartilage Chondrocyte Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Response To Hypoxia Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Relaxation Of Vascular Smooth Muscle Regulation Of Cell Growth CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?		advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?