NPR1 and NPPC

Number of citations of the paper that reports this interaction (PMID 1660465)
16

Data Source:
BioGRID (pull down)

		NPR1	NPPC
Gene Name		natriuretic peptide receptor 1	natriuretic peptide C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex	Extracellular Space Secretory Granule
	Molecular Function	Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding	Receptor Binding Hormone Activity Protein Homodimerization Activity Peptide Hormone Receptor Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth Positive Regulation Of CGMP Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vasodilation Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Proliferation Post-embryonic Development Regulation Of CAMP Metabolic Process Regulation Of CGMP Metabolic Process Positive Regulation Of CGMP Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Drug Single Organism Reproductive Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Vasodilation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size Negative Regulation Of DNA Metabolic Process Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation
Pathways
Drugs		Nitroprusside Nitroglycerin Isosorbide Dinitrate Amyl Nitrite Erythrityl Tetranitrate Nesiritide
Diseases
GWAS			Height ( 20881960 19570815 18391951)
Protein-Protein Interactions		5 interactors: ATF7IP NPPA NPPB NPPC PRKG1	4 interactors: MME NPR1 NPR2 NPR3
Entrez ID		4881	4880
HPRD ID		00165	08975
Ensembl ID		ENSG00000169418
Uniprot IDs		P16066	E5LCN7 P23582
PDB IDs			1JDP
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Size Regulation Of Tube Size Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Circulation Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Cell Growth Regulation Of Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Blood Pressure Negative Regulation Of Oocyte Maturation Organophosphate Metabolic Process Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Muscle System Process Growth Plate Cartilage Chondrocyte Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Response To Hypoxia Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Relaxation Of Vascular Smooth Muscle Regulation Of Cell Growth CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume	Regulation Of Blood Pressure Blood Circulation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Negative Regulation Of Oocyte Development Osteoclast Proliferation Creatinine Metabolic Process Ribonucleotide Metabolic Process Response To UV-A Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Pancreatic Juice Secretion Cellular Response To UV-B Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Angiotensin Maturation Intracellular Signal Transduction Regulation Of Angiotensin Metabolic Process Positive Regulation Of Renal Sodium Excretion Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To UV-B Replicative Senescence Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Beta-amyloid Metabolic Process Positive Regulation Of CGMP Metabolic Process Skeletal System Development Nucleotide Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Small Molecule Metabolic Process Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of CGMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Regulation Of Osteoblast Proliferation
Tagcloud ?		advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic
Tagcloud (Difference) ?		advantages asset bands bzip complemented elusive ethylene interacting interested isolating offers overexpressing oxylipin powerful proteolytically pull purification purifying researchers salicylic stimulus tag tagged tagging tap tga2 tga5 tga6 xenobiotic
Tagcloud (Intersection) ?