HOXD4 and HOXB13

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		HOXD4	HOXB13
Name		homeobox D4	homeobox B13
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Morphogenesis Of An Epithelium Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Epidermis Development Response To Wounding Prostate Gland Development Response To Testosterone Regulation Of Growth Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	None
GWAS		Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Prostate cancer ( 23104005 23535732 )
Novel Interactors		None recorded	1 novel interactors: RAB5C
Interacting Genes		21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	7 interacting genes: ALX4 ELK1 HOXD4 IRF4 MEIS1 POU2F1 ZNF490
Entrez ID		3233	10481
HPRD ID		00864	05210
Ensembl ID		ENSG00000170166	ENSG00000159184
Uniprot IDs		P09016	Q4KR72 Q92826
PDB IDs		Not available	2CRA 5EDN 5EEA 5EF6 5EG0 5EGO 5NO6 7PSX 8BYX
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nucleus Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3K27 Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Eye Development Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Animal Organ Morphogenesis Sensory Organ Development Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Damaged DNA Binding N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Pattern Specification Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Heat Definitive Hemopoiesis	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Pattern Specification Process Embryonic Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Skeletal System Morphogenesis Positive Regulation Of Metabolic Process Hippocampal Neuron Apoptotic Process Animal Organ Morphogenesis Embryonic Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Mediator Complex Binding Animal Organ Development Anterior/posterior Pattern Specification Cellular Response To Testosterone Stimulus Regulation Of Metabolic Process Cell Growth Involved In Cardiac Muscle Cell Development Plasma Membrane To Endosome Transport Cellular Developmental Process Transcription Regulator Activator Activity Nucleus Transcription Regulator Complex HMG Box Domain Binding Transcription Cis-regulatory Region Binding T-helper 17 Cell Lineage Commitment Regionalization Lens Morphogenesis In Camera-type Eye Positive Regulation Of Interleukin-13 Production