HOXD4 and RXRG

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		HOXD4	RXRG
Name		homeobox D4	retinoid X receptor gamma
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Molecular Condensate Scaffold Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Stem Cell Differentiation	Regulation Of DNA-templated Transcription Nervous System Development Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs		None	Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
GWAS		Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )	AIDS ( 19754311 ) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468 ) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Macular thickness ( 30535121 ) Menarche (age at onset) ( 21102462 25231870 27182965 29773799 ) Metabolite levels ( 23823483 ) Personality traits in bipolar disorder ( 21368711 ) Proportion of activated microglia (midfrontal cortex) ( 30679421 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		None recorded	1 novel interactors: FBXL4
Interacting Genes		21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	33 interacting genes: CAMK2B CEBPZ CHGB CKMT1A CKMT1B CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 NRIP1 PICK1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		3233	6258
HPRD ID		00864	01579
Ensembl ID		ENSG00000170166	ENSG00000143171
Uniprot IDs		P09016	A0A087WZ88 F1D8Q7 F1T097 P48443
PDB IDs		Not available	2GL8 7A79
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nucleus Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3K27 Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Eye Development Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Animal Organ Morphogenesis Sensory Organ Development Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Damaged DNA Binding N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Pattern Specification Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Heat Definitive Hemopoiesis	Nuclear Receptor Activity Nuclear Retinoid X Receptor Binding Intracellular Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Chromatin Sequence-specific DNA Binding Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process MRNA Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process MRNA Transcription Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Chromatin DNA Binding Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Ketone Metabolic Process DNA-templated Transcription Negative Regulation Of Macrophage Derived Foam Cell Differentiation DNA Binding Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Trachea Cartilage Development Regulation Of Lipid Storage