HOXD4 and ETV4

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		HOXD4	ETV4
Name		homeobox D4	ETS variant transcription factor 4
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Stem Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	MAPK6/MAPK4 signaling
Diseases		None	Prostate cancer Ewing's sarcoma
GWAS		Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	15 interacting genes: APP ATXN1 EP300 EPAS1 HIF1A HOXD4 HTT JUN MEOX2 NFE2L2 SAE1 SMAD4 SRF STK11 UBA2
Entrez ID		3233	2118
HPRD ID		00864	02833
Ensembl ID		ENSG00000170166	ENSG00000175832
Uniprot IDs		P09016	P43268
PDB IDs		Not available	4CO8 4UUV 5ILU
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nucleus Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3K27 Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Eye Development Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Animal Organ Morphogenesis Sensory Organ Development Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Damaged DNA Binding N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Pattern Specification Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Heat Definitive Hemopoiesis	Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Learning Or Memory DNA Binding Transcription Coactivator Binding Response To Hypoxia Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Response To Decreased Oxygen Levels Cognition Learning Response To Oxygen Levels Positive Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Hemopoiesis Nucleoplasm Nucleus P53 Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Positive Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Associative Learning Transcription Regulator Complex Sequence-specific DNA Binding Negative Regulation Of MiRNA Transcription Chromatin Binding Positive Regulation Of Multicellular Organismal Process Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Transport Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Nervous System Process