AP4M1 and GRIN2A

Number of citations of the paper that reports this interaction (PMID 15254094)
68

Data Source:
HPRD (two hybrid)

		AP4M1	GRIN2A
Gene Name		adaptor-related protein complex 4, mu 1 subunit	glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Image
Gene Ontology Annotations	Cellular Component	Golgi Trans Cisterna Trans-Golgi Network Coated Pit AP-type Membrane Coat Adaptor Complex Clathrin Adaptor Complex Extracellular Vesicular Exosome	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Presynaptic Membrane Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Transporter Activity	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Vesicle-mediated Transport	Startle Response Response To Amphetamine Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Learning Or Memory Memory Protein Localization Visual Learning Response To Wounding Sensory Perception Of Pain Neurogenesis Sleep Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Hepatitis B ( 22004137) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		13 interactors: AP4B1 ARF1 CACNG3 CD63 CHTF8 DDX52 GRID2 GRIN2A GRIN2B LAMP2 TGOLN2 USP47 ZBTB22	27 interactors: ACTN1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN3A GRIN3B IL16 INADL NEDD4 PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC
Entrez ID		9179	2903
HPRD ID		03803	00698
Ensembl ID		ENSG00000221838	ENSG00000183454
Uniprot IDs		C9JC87 O00189	B4DII7 F5GZ52 Q12879 Q547U9 Q59EW6
PDB IDs		3L81	3NFL
Enriched GO Terms of Interacting Partners?		Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Depolarization Neuromuscular Process Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Calcium Ion Transmembrane Transport Synaptic Transmission Regulation Of Membrane Potential Regulation Of Synaptic Transmission Calcium Ion Transport Platelet Degranulation Transport Cell-cell Signaling Sensory Perception Of Pain Protein Localization Memory Directional Locomotion Regulation Of Signaling Learning Response To Ethanol Regulation Of Rubidium Ion Transport Ion Transmembrane Transport Regulation Of Endocytosis Platelet Activation Pigment Granule Maturation Endosome To Melanosome Transport Vesicle-mediated Transport Cellular Localization Response To Wounding Monoubiquitinated Protein Deubiquitination Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Cerebellar Granule Cell Differentiation Negative Regulation Of Cell Cycle G2/M Phase Transition Golgi Vesicle Budding Metal Ion Transport Learning Or Memory Prepulse Inhibition Serotonin Metabolic Process Sleep	Synaptic Transmission Cell-cell Signaling Protein Localization To Synapse Chemotaxis Neuron Projection Development Receptor Localization To Synapse Neuron Development Locomotion Axon Guidance Regulation Of Ion Transport Neuron Differentiation Cell Projection Organization Response To External Stimulus Protein Autophosphorylation Receptor Clustering Generation Of Neurons Axonogenesis Nucleotide Phosphorylation Neurogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Membrane Organization Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Regulation Of Synaptic Plasticity Nervous System Development Cell Morphogenesis Involved In Differentiation Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Cell Projection Morphogenesis Cell Development Peptidyl-serine Phosphorylation Cell Part Morphogenesis Phosphorylation Signaling Regulation Of Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell Communication Cell Activation Phosphate-containing Compound Metabolic Process Glutamate Receptor Signaling Pathway Cell Differentiation Response To Stimulus Immune Response Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?			6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?