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AP4M1 and GRIN2B
Number of citations of the paper that reports this interaction (PMID
15254094
)
68
Data Source:
HPRD
(two hybrid)
AP4M1
GRIN2B
Gene Name
adaptor-related protein complex 4, mu 1 subunit
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image
Gene Ontology Annotations
Cellular Component
Golgi Trans Cisterna
Trans-Golgi Network
Coated Pit
AP-type Membrane Coat Adaptor Complex
Clathrin Adaptor Complex
Extracellular Vesicular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Neuron Projection
Postsynaptic Membrane
Neuronal Postsynaptic Density
Molecular Function
Transporter Activity
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Protein Binding
Zinc Ion Binding
Glycine Binding
Biological Process
Intracellular Protein Transport
Golgi To Endosome Transport
Vesicle-mediated Transport
Behavioral Fear Response
In Utero Embryonic Development
Startle Response
Suckling Behavior
Transport
Glutamate Receptor Signaling Pathway
Synaptic Transmission
Axon Guidance
Sensory Organ Development
Learning Or Memory
Learning
Memory
Regulation Of Protein Kinase A Signaling
Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Response To Ethanol
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Behavioral Response To Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Regulation Of Excitatory Postsynaptic Membrane Potential
Calcium Ion Transmembrane Transport
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Drugs
L-Glutamic Acid
Meperidine
Haloperidol
Felbamate
Memantine
Tenocyclidine
Diseases
GWAS
Aging (time to event) (
21782286
)
Brain structure (temporal lobe volume) (
20197096
)
Cognitive performance (
19734545
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Major depressive disorder (
23377640
)
Ovarian reserve (
22116950
)
Total ventricular volume (
21116278
)
Protein-Protein Interactions
13 interactors:
AP4B1
ARF1
CACNG3
CD63
CHTF8
DDX52
GRID2
GRIN2A
GRIN2B
LAMP2
TGOLN2
USP47
ZBTB22
40 interactors:
ACTN2
AP1M1
AP2M1
AP4M1
ARHGAP32
CAMK2A
CAMK2B
CAMK2D
CAMK2G
CAMK2N1
CAPN1
DLG1
DLG2
DLG3
DLG4
EPHB2
ERBB2IP
EXOC4
EXOC7
FYN
GNB2L1
GRIN1
GRIN3A
IL16
INADL
LIN7A
LIN7B
MAGI3
MIB2
PARK2
PIK3CA
PLCG1
PRKCA
PRKCB
PRKCG
PTPN11
SPTAN1
SRC
SYNGAP1
TANC1
Entrez ID
9179
2904
HPRD ID
03803
00697
Ensembl ID
ENSG00000221838
Uniprot IDs
C9JC87
O00189
Q13224
PDB IDs
3L81
1S11
1S2S
2IPV
Enriched GO Terms of Interacting Partners
?
Startle Response
Synaptic Transmission, Glutamatergic
Ionotropic Glutamate Receptor Signaling Pathway
Glutamate Receptor Signaling Pathway
Neuron-neuron Synaptic Transmission
Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Postsynaptic Membrane Potential
Membrane Depolarization
Neuromuscular Process
Regulation Of Synaptic Plasticity
Regulation Of Receptor Internalization
Calcium Ion Transmembrane Transport
Synaptic Transmission
Regulation Of Membrane Potential
Regulation Of Synaptic Transmission
Calcium Ion Transport
Platelet Degranulation
Transport
Cell-cell Signaling
Sensory Perception Of Pain
Protein Localization
Memory
Directional Locomotion
Regulation Of Signaling
Learning
Response To Ethanol
Regulation Of Rubidium Ion Transport
Ion Transmembrane Transport
Regulation Of Endocytosis
Platelet Activation
Pigment Granule Maturation
Endosome To Melanosome Transport
Vesicle-mediated Transport
Cellular Localization
Response To Wounding
Monoubiquitinated Protein Deubiquitination
Positive Regulation Of Integrin-mediated Signaling Pathway
Cellular Pigment Accumulation
Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
COPI-coated Vesicle Budding
COPI Coating Of Golgi Vesicle
Cerebellar Granule Cell Differentiation
Negative Regulation Of Cell Cycle G2/M Phase Transition
Golgi Vesicle Budding
Metal Ion Transport
Learning Or Memory
Prepulse Inhibition
Serotonin Metabolic Process
Sleep
Synaptic Transmission
Cell-cell Signaling
Membrane Organization
Establishment Or Maintenance Of Apical/basal Cell Polarity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Chemotaxis
Signaling
Cell Communication
Axon Guidance
Cell Projection Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Neuron Projection Development
Receptor Localization To Synapse
Regulation Of Neuronal Synaptic Plasticity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Movement Of Cell Or Subcellular Component
Axonogenesis
Protein Autophosphorylation
Regulation Of Long-term Neuronal Synaptic Plasticity
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Signaling
Neurotrophin TRK Receptor Signaling Pathway
Neuron Development
Neurotrophin Signaling Pathway
Learning
Response To Stimulus
Neuron Projection Morphogenesis
Nervous System Development
Locomotion
Fibroblast Growth Factor Receptor Signaling Pathway
Learning Or Memory
Response To External Stimulus
Ephrin Receptor Signaling Pathway
Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Neuron Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Protein Localization To Synapse
Protein Localization
Receptor Clustering
Cognition
Blood Coagulation
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Body Fluid Levels
Cellular Response To Stimulus
Hemostasis
Platelet Activation
Tagcloud
?
6j
6jxm
atg
autosomes
backcross
codon
crosses
dispersed
egr
epsilon
espilon
exons
f1xc57bl
flanking
grinl
interspecific
mapping
nucleas
polyadenylation
primer
s1
spans
spl
spretus
termination
zeta
Tagcloud (Difference)
?
6j
6jxm
atg
autosomes
backcross
codon
crosses
dispersed
egr
epsilon
espilon
exons
f1xc57bl
flanking
grinl
interspecific
mapping
nucleas
polyadenylation
primer
s1
spans
spl
spretus
termination
zeta
Tagcloud (Intersection)
?