MXD4 and MLX

Number of citations of the paper that reports this interaction (PMID 11230181)
26

Data Source:
HPRD (in vivo, in vitro)

		MXD4	MLX
Gene Name		MAX dimerization protein 4	MLX, MAX dimerization protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Positive Regulation Of Cellular Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Integration of energy metabolism ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		6 interactors: MAX MLX SHBG SIN3A SMC3 TCP10L	13 interactors: AES APP GABARAPL2 ID3 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP ZBTB32
Entrez ID		10608	6945
HPRD ID		10103	04278
Ensembl ID		ENSG00000123933	ENSG00000108788
Uniprot IDs		Q14582	Q9UH92
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Methylglyoxal Primary Spermatocyte Growth Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chromatin Silencing Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of DNA Endoreduplication RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Endoreduplication Nitrogen Compound Metabolic Process Mitotic Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress RNA Metabolic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Defense Response To Virus By Host Cellular Response To Stress Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Gene Expression Negative Regulation Of Histone Acetylation Regulation Of Gene Silencing Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Acetylation Regulation Of Transcription Regulatory Region DNA Binding Macromolecule Biosynthetic Process Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Defense Response To Virus By Host Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Spindle Organization Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Response To Wounding Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of DNA Replication	Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metaphase Plate Congression Glucose Mediated Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Protein Processing Carbohydrate Mediated Signaling Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Protein Binding
Tagcloud ?		activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Difference) ?		activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Intersection) ?