MXD4 and MLX

Number of citations of the paper that reports this interaction (PubMedID 11230181)
0

Data Source:
HPRD (in vitro, in vivo)

		MXD4	MLX
Description		MAX dimerization protein 4	MAX dimerization protein MLX
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4	ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Monocyte count ( 32888494)	Crohn's disease ( 21102463) Type 2 diabetes ( 29632382 30297969 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: MAX MLX SHBG SIN3A SMC3 TCP10L	31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620
Entrez ID		10608	6945
HPRD ID		10103	04278
Ensembl ID		ENSG00000123933	ENSG00000108788
Uniprot IDs		Q14582	Q9UH92
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Myc-Max Complex Negative Regulation Of RNA Metabolic Process Mad-Max Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Meiotic Sister Chromatid Cohesion Protein Dimerization Activity DNA-binding Transcription Factor Binding Androgen Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Meiotic Cohesin Complex Mediator Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Cellular Response To Dopamine Transcription Corepressor Activity Establishment Of Sister Chromatid Cohesion Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hydroperoxide DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Biosynthetic Process Negative Regulation Of Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Lateral Element Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Mitotic Sister Chromatid Cohesion Cellular Response To Catecholamine Stimulus Negative Regulation Of Metabolic Process Dynein Complex Binding Sin3-type Complex Response To Catecholamine Response To Hydroperoxide Cerebral Cortex Neuron Differentiation	Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Somite Specification RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Nitrogen Starvation Regulation Of Macromolecule Metabolic Process Phosphatidylethanolamine Binding Regulation Of Gene Expression Segment Specification Somite Development GABA Receptor Binding Positive Regulation Of ATP-dependent Activity SUMO Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Leptomycin B Leptomycin B Binding Regulation Of ATP-dependent Activity SUMO Conjugating Enzyme Activity MAD1 Complex Carbohydrate Response Element Binding Primary Adaptive Immune Response Involving T Cells And B Cells Coated Vesicle Membrane Positive Regulation Of ATP Metabolic Process Negative Regulation Of Metabolic Process
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