MXD4 and MAX

Number of citations of the paper that reports this interaction (PMID 8521822)
57

Data Source:
HPRD (in vitro)

		MXD4	MAX
Gene Name		MAX dimerization protein 4	MYC associated factor X
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm PML Body Dendrite MLL1 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Protein Complex Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cell Proliferation	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Response To Starvation Negative Regulation Of Gene Expression Response To Insulin Response To Axon Injury Neuron Apoptotic Process Retina Development In Camera-type Eye Cellular Response To Peptide Hormone Stimulus
Pathways			G1/S Transition Cyclin E associated events during G1/S transition S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Anthropometric traits ( 19260139) Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		6 interactors: MAX MLX SHBG SIN3A SMC3 TCP10L	43 interactors: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TCF3 TEAD1 TRRAP TUBA1A TXLNG UNC45A ZBTB17
Entrez ID		10608	4149
HPRD ID		10103	01113
Ensembl ID		ENSG00000123933	ENSG00000125952
Uniprot IDs		Q14582	P61244 Q8TAX8
PDB IDs			1AN2 1HLO 1NKP 1NLW 1R05
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Methylglyoxal Primary Spermatocyte Growth Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Chromatin Silencing Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of DNA Endoreduplication RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Endoreduplication Nitrogen Compound Metabolic Process Mitotic Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress RNA Metabolic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Defense Response To Virus By Host Cellular Response To Stress Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Gene Expression Negative Regulation Of Histone Acetylation Regulation Of Gene Silencing Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Cell Cycle Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Acetylation Regulation Of Transcription Regulatory Region DNA Binding Macromolecule Biosynthetic Process Sister Chromatid Cohesion Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Defense Response To Virus By Host Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Spindle Organization Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Response To Wounding Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of DNA Replication	RNA Biosynthetic Process RNA Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tube Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cell Division Multicellular Organismal Development Negative Regulation Of Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryo Development Positive Regulation Of Cell Development Regulation Of Cellular Process Cellular Metabolic Process
Tagcloud ?		activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Difference) ?		activators argonaute box downregulating elevate enter feed forward implicate interferon interplay irf irf3 mediate mediating micrornas mir mirna mirnas mobility modulating myc networks preventing quiescence quiescent repressor suppresses transition	aminoiminomethyl behaves competitive dichloro dimethylquinolin displaced giving henyl int ips lf m1 muscarinic nonpeptide oxymethyl pa2 phenylcarbonyl phosphoinositosides piperazin plot pyrrolidine rbonyl saturation schild shifted slope sulphonyl umbilical unity yl
Tagcloud (Intersection) ?