MXD4 and MAX

Number of citations: 60 (PubMedID 8521822)
Data Source: HPRD (in vitro)

		MXD4	MAX
Name		MAX dimerization protein 4	MYC associated factor X
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Dendrite Protein-DNA Complex Cell Projection Mad-Max Complex MLL1 Complex Myc-Max Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4	Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
GWAS		HDL cholesterol levels ( 32203549 ) Monocyte count ( 32888494 )	Anthropometric traits ( 19260139 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Blood trace element (Zn levels) ( 23720494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 27863252 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		6 interacting genes: MAX MLX SHBG SIN3A SMC3 TCP10L	43 interacting genes: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TEAD1 TRRAP TUBA1A TXLNG UNC45A USP1 ZBTB17
Entrez ID		10608	4149
HPRD ID		10103	01113
Ensembl ID		ENSG00000123933	ENSG00000125952
Uniprot IDs		Q14582	G3V302 G3V563 G3V5L1 P61244 Q6V3B1 Q8TAX8
PDB IDs		Not available	1AN2 1HLO 1NKP 1NLW 1R05 5EYO 6G6J 6G6K 6G6L 8OTS 8OTT
GO Terms Enriched among Interactors		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Myc-Max Complex Negative Regulation Of RNA Metabolic Process Mad-Max Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Meiotic Sister Chromatid Cohesion Protein Dimerization Activity DNA-binding Transcription Factor Binding Androgen Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Meiotic Cohesin Complex Mediator Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Cellular Response To Dopamine Transcription Corepressor Activity Establishment Of Sister Chromatid Cohesion Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hydroperoxide DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Biosynthetic Process Negative Regulation Of Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Lateral Element Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Mitotic Sister Chromatid Cohesion Cellular Response To Catecholamine Stimulus Negative Regulation Of Metabolic Process Dynein Complex Binding Sin3-type Complex Response To Catecholamine Response To Hydroperoxide Cerebral Cortex Neuron Differentiation	Protein Dimerization Activity Chromatin Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Binding Nucleoplasm DNA Binding Positive Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Regulation Of MiRNA Metabolic Process Response To UV Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta2 Production Response To Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Neddylation Positive Regulation Of RNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of Macromolecule Metabolic Process Striated Muscle Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process