CHMP1A and VPS4B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHMP1A	VPS4B
Description		charged multivesicular body protein 1A	vacuolar protein sorting 4 homolog B
Image
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore Condensed Nuclear Chromosome ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Multivesicular Body Microtubule Organizing Center Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Nuclear Matrix Midbody Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane	Spindle Pole Nucleus Nuclear Pore Cytoplasm Endosome Centrosome Cytosol Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome Flemming Body ATPase Complex
	Molecular Function	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Chromosome Condensation Mitotic Metaphase Chromosome Alignment Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly	Angiogenesis Plasma Membrane Repair Potassium Ion Transport Autophagy Nucleus Organization Endosome Organization Vacuole Organization Vacuolar Transport Lysosomal Transport Mitotic Metaphase Chromosome Alignment Central Nervous System Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Cholesterol Transport Nuclear Membrane Reassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Canonical Wnt Signaling Pathway Establishment Of Blood-brain Barrier Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways		HCMV Late Events	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Basal cell carcinoma ( 33549134) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Estimated glomerular filtration rate ( 31152163) Hemoglobin levels ( 32327693) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Plasma homocysteine levels ( 30339177) Red vs. brown/black hair color ( 30531825)	Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		18 interacting genes: C14orf119 CHMP1B DDIT4L GORASP2 LNPK MITD1 NR1I2 PSMA1 SDCBP STAMBP TXN2 UBE2I USP8 VPS4A VPS4B VTA1 YES1 ZDHHC17	10 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 OGT VPS4A ZFYVE19
Entrez ID		5119	9525
HPRD ID		01237	15653
Ensembl ID		ENSG00000131165	ENSG00000119541
Uniprot IDs		A0A6Q8PFX8 Q9HD42	O75351
PDB IDs		2JQ9 2YMB 4A5X	1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y 7L9X
Enriched GO Terms of Interacting Partners?		ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Midbody Abscission Nuclear Membrane Reassembly Viral Budding Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Viral Budding From Plasma Membrane Membrane Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Midbody Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Nuclear Pore Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Endosome Membrane Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle Organization Membrane Fission Protein-containing Complex Disassembly Viral Process Mitotic Metaphase Chromosome Alignment Late Endosome Membrane Autophagosome Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Metaphase Chromosome Alignment Mitotic Cytokinesis Mitotic Nuclear Membrane Reassembly ATPase Complex Chromosome Localization Cell Division Extracellular Exosome Positive Regulation Of Exocytosis Nucleus Organization Proteolysis	Midbody Abscission Mitotic Cytokinetic Process ESCRT III Complex Disassembly ESCRT Complex Disassembly Cytokinetic Process Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Viral Budding Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Membrane Fission Multivesicular Body-lysosome Fusion Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Lysosomal Membrane Organization Metaphase Chromosome Alignment Membrane Assembly Midbody Kinetochore Microtubule Chromosome Localization Regulation Of Mitotic Spindle Assembly Endosome Organization Nuclear Pore Nucleus Organization Multivesicular Body Membrane Vesicle Fusion Organelle Membrane Fusion Regulation Of Spindle Assembly Plasma Membrane Organization Lysosomal Transport Autophagy Organelle Fusion Regulation Of Mitotic Spindle Organization Protein-containing Complex Disassembly Multivesicular Body Viral Process Regulation Of Centrosome Duplication Membrane Fusion
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