CHMP1A and USP8

Number of citations of the paper that reports this interaction (PMID 19302785)
6

Data Source:
BioGRID (pull down)

		CHMP1A	USP8
Gene Name		charged multivesicular body protein 1A	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome ESCRT III Complex Early Endosome Microtubule Organizing Center Endomembrane System Nuclear Matrix Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytokinesis Cell Separation After Cytokinesis Transcription, DNA-templated Proteolysis Nucleus Organization Vacuolar Transport Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Gene Silencing Negative Regulation Of Transcription By Glucose Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Spindle Assembly	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways			Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CHMP1B KIAA1715 NR1I2 STAMBP UBE2I USP8 VPS4A VPS4B ZDHHC17	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		5119	9101
HPRD ID		01237	04405
Ensembl ID		ENSG00000131165	ENSG00000138592
Uniprot IDs		A6NG32 Q9HD42	P40818
PDB IDs		2JQ9 2YMB 4A5X	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Cell Division Cell Separation After Cytokinesis Mitotic Cell Cycle Process Cytokinesis Mitotic Cell Cycle Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Cell Cycle Process Chromosome Segregation Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Cell Cycle Mitotic Sister Chromatid Segregation Mitotic Nuclear Division Regulation Of Mitotic Spindle Assembly Sister Chromatid Segregation Viral Budding Regulation Of Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Nucleus Organization Regulation Of Mitotic Spindle Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Protein Catabolic Process Protein Catabolic Process Endosome Organization Regulation Of Cell Division Proteolysis Regulation Of Centrosome Duplication Mitotic Cytokinesis Regulation Of Centrosome Cycle Cellular Macromolecule Catabolic Process Establishment Of Organelle Localization Positive Regulation Of Exocytosis Catabolic Process Drug Export Negative Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of SUMO Transferase Activity Membrane Budding Organelle Localization Regulation Of Cell Cycle Process Vacuole Organization Protein Deubiquitination Positive Regulation Of Centriole Replication	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		aux1 auxin disorganized endosomal escrt gradients internalized lip5 lumenal meristems mislocalized multivesicular mvb mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		aux1 auxin disorganized endosomal escrt gradients internalized lip5 lumenal meristems mislocalized multivesicular mvb mvbs pin1 pin2 pinformed1 protein1a resistant1 rudimentary seedling seedlings skd1 sorted stomata symmetry thaliana vacuolar	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?