ADAM33 and EPGN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM33	EPGN
Description		ADAM metallopeptidase domain 33	epithelial mitogen
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GO Annotations	Cellular Component	Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Proteolysis	MAPK Cascade Angiogenesis Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation
Pathways		Regulation of CDH11 function	PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases		Asthma
GWAS		Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Breast size ( 22747683) Immune reponse to smallpox (secreted IL-1beta) ( 22610502)
Interacting Genes		33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21	4 interacting genes: ADAM33 CXCL9 MTIF3 TIMMDC1
Entrez ID		80332	255324
HPRD ID		06173	10866
Ensembl ID		ENSG00000149451	ENSG00000182585
Uniprot IDs		A2A2L3 Q9BZ11	Q6UW88
PDB IDs		1R54 1R55	5WB8
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane
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