ADAM33 and ASGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM33	ASGR2
Description		ADAM metallopeptidase domain 33	asialoglycoprotein receptor 2
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GO Annotations	Cellular Component	Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding
	Biological Process	Proteolysis	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway
Pathways		Regulation of CDH11 function	Asparagine N-linked glycosylation
Drugs			Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases		Asthma
GWAS		Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)	Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)
Interacting Genes		33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21	50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1
Entrez ID		80332	433
HPRD ID		06173	00152
Ensembl ID		ENSG00000149451	ENSG00000161944
Uniprot IDs		A2A2L3 Q9BZ11	P07307 Q7Z4G9
PDB IDs		1R54 1R55	8URF
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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