DCUN1D1 and UBE2F

Number of citations of the paper that reports this interaction (PubMedID 23201271)
53

Data Source:
BioGRID (pull down, pull down)

		DCUN1D1	UBE2F
Description		defective in cullin neddylation 1 domain containing 1	ubiquitin conjugating enzyme E2 F (putative)
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Nucleotide Binding Protein Binding ATP Binding Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity NEDD8 Ligase Activity
	Biological Process	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Defense Response To Virus
Pathways		Neddylation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)	Lean body mass ( 28552196)
Interacting Genes		32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	13 interacting genes: CUL1 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RBX1 RC3H1 RNF34 RNF7 TRIM2 UBA3
Entrez ID		54165	140739
HPRD ID		12067	14812
Ensembl ID		ENSG00000043093	ENSG00000184182
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q969M7
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3	2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cullin Family Protein Binding Protein Modification Process NEDD8 Transferase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Neddylation NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination NEDD8 Ligase Activity Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Macromolecule Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Cytoplasm Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Stress Response To Cytokine Response To Peptide Cellular Response To Interleukin-1 Positive Regulation Of Hippocampal Neuron Apoptotic Process
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