DCUN1D1 and ABRAXAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DCUN1D1	ABRAXAS2
Description		defective in cullin neddylation 1 domain containing 1	abraxas 2, BRISC complex subunit
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Midbody Spindle Pole Centrosome Ciliary Basal Body Microtubule Minus-end BRISC Complex
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly
Pathways		Neddylation	Metalloprotease DUBs
Drugs
Diseases
GWAS		Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)	Bone mineral content ( 31790847)
Interacting Genes		32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	7 interacting genes: DCUN1D1 NUMA1 OGT SMURF2 THAP5 UBC USP7
Entrez ID		54165	23172
HPRD ID		12067	13783
Ensembl ID		ENSG00000043093	ENSG00000165660
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q15018
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3	6H3C 6R8F 8PVY 8PY2
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation	Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Protein Ubiquitination Cortical Microtubule Anastral Spindle Assembly Nucleoplasm Regulation Of Cellular Response To Growth Factor Stimulus Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Nucleus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Mitotic Spindle Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Arginyl-tRNA--protein Transferase Activity Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Protein Localization To Vacuole Lateral Cell Cortex Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Protein Arginylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway Cell Cortex Region Regulation Of Cellular Localization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Mitotic Spindle Astral Microtubule Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Microtubule Bundle Regulation Of Protein Localization To Cell Periphery Regulation Of TOR Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Ubiquitin-like Protein Binding
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