DCUN1D1 and CDIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DCUN1D1	CDIP1
Description		defective in cullin neddylation 1 domain containing 1	cell death inducing p53 target 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Neddylation
Drugs
Diseases
GWAS		Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)	A body shape index ( 34021172) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 28991256) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B	16 interacting genes: ATXN1 CCR2 DCUN1D1 DESI1 EPN2 LAT NEDD4 OTUB2 OTUD7B TNIP1 TOLLIP UBB UBC UBQLN1 UBQLN2 YAP1
Entrez ID		54165	29965
HPRD ID		12067	12676
Ensembl ID		ENSG00000043093	ENSG00000089486
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q9H305
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation	Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Post-translational Protein Modification Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytosol Regulation Of Macromolecule Metabolic Process Protein Tag Activity Ubiquitin Binding Proline-rich Region Binding Positive Regulation Of ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Cytoplasm Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Macromolecule Catabolic Process Regulation Of ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Proteolysis Ubiquitin Conjugating Enzyme Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein-containing Complex Negative Regulation Of Transport Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy
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