RPL30 and USP40

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		RPL30	USP40
Description		ribosomal protein L30	ubiquitin specific peptidase 40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Cytoplasmic Translation Translation Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		16 interacting genes: APP CASP2 DUX4 ERCC6 FAM120B G0S2 IL7R MAP2K7 MAP3K14 NEDD4L NFKB2 OAS1 OGT PTEN USP40 ZFAND2A	45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA
Entrez ID		6156	55230
HPRD ID		01595	07166
Ensembl ID		ENSG00000156482	ENSG00000085982
Uniprot IDs		P62888	A0A7I2YQ75 C9JK14 Q9NVE5
PDB IDs		3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKY 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Rhythmic Process Cytosol Enzyme Binding Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Proteolysis Positive Regulation Of Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Molecular Function Activator Activity Positive Regulation Of Signal Transduction Dendritic Spine Reproductive Behavior Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Peptidyl-serine Phosphorylation Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Hemopoiesis Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Neuron Projection Organization Cellular Developmental Process Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Response To Mechanical Stimulus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Neuron Projection Development Modulation Of Excitatory Postsynaptic Potential	Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome
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