PAM

Description		peptidylglycine alpha-amidating monooxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Catalytic Activity Monooxygenase Activity Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity L-ascorbic Acid Binding Metal Ion Binding
	Biological Process	Peptide Amidation Peptide Metabolic Process Lipid Metabolic Process Response To Zinc Ion Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fatty Acid Primary Amide Biosynthetic Process
Pathways
Drugs		Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Daytime nap ( 33568662) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Nicotine dependence symptom count ( 25555482) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 30297969 29632382 29358691) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: TBCA
Interacting Genes		9 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		5066
HPRD ID		01361
Ensembl ID		ENSG00000145730
Uniprot IDs		A0A804HIQ0 A0A804HKM7 A0A804HKV8 A0A8C8KD64 O43832 P19021
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Heart Contraction Regulation Of Blood Circulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Translational Initiation Response To Peptide Hormone Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Protein Glutathionylation Positive Regulation Of Oxytocin Production Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Dense Core Granule Biogenesis Protein Serine Kinase Activity Protein Phosphorylation Histone H3T6 Kinase Activity Phosphorylation Trans-Golgi Network Transport Vesicle Membrane Glucagon Receptor Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Translation Alphav-beta3 Integrin-PKCalpha Complex Protein Serine/threonine Kinase Activity Regulation Of Translational Initiation TSC1-TSC2 Complex Intracellular Signal Transduction Regulation Of Cell Cycle Cellular Pigmentation Type 1 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Protein Kinase C Signaling Transmembrane Transporter Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Response To Psychosocial Stress Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Signal Transduction Vesicle-mediated Transport Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane
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