PAM and RASSF9

Number of citations of the paper that reports this interaction (PubMedID 9837933)
0

Data Source:
HPRD (two hybrid, in vitro)

		PAM	RASSF9
Description		peptidylglycine alpha-amidating monooxygenase	Ras association domain family member 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome	Endosome Cytosol Trans-Golgi Network Transport Vesicle Membrane Recycling Endosome Extracellular Exosome
	Molecular Function	Catalytic Activity Monooxygenase Activity Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity L-ascorbic Acid Binding Metal Ion Binding	Protein Binding
	Biological Process	Peptide Amidation Peptide Metabolic Process Lipid Metabolic Process Response To Zinc Ion Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fatty Acid Primary Amide Biosynthetic Process	Protein Targeting Signal Transduction Endosomal Transport Intracellular Transport
Pathways
Drugs		Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Daytime nap ( 33568662) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Nicotine dependence symptom count ( 25555482) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 30297969 29632382 29358691) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172)	Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nose size ( 27182965)
Interacting Genes		9 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TSC2 UHMK1	2 interacting genes: HSPB1 PAM
Entrez ID		5066	9182
HPRD ID		01361	08826
Ensembl ID		ENSG00000145730	ENSG00000198774
Uniprot IDs		A0A804HIQ0 A0A804HKM7 A0A804HKV8 A0A8C8KD64 O43832 P19021	O75901
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Heart Contraction Regulation Of Blood Circulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Translational Initiation Response To Peptide Hormone Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Protein Glutathionylation Positive Regulation Of Oxytocin Production Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Dense Core Granule Biogenesis Protein Serine Kinase Activity Protein Phosphorylation Histone H3T6 Kinase Activity Phosphorylation Trans-Golgi Network Transport Vesicle Membrane Glucagon Receptor Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Translation Alphav-beta3 Integrin-PKCalpha Complex Protein Serine/threonine Kinase Activity Regulation Of Translational Initiation TSC1-TSC2 Complex Intracellular Signal Transduction Regulation Of Cell Cycle Cellular Pigmentation Type 1 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Protein Kinase C Signaling Transmembrane Transporter Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Response To Psychosocial Stress Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Signal Transduction Vesicle-mediated Transport Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane	Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Peptide Amidation Protein Kinase C Inhibitor Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Cellular Response To Growth Factor Stimulus Hyaloid Vascular Plexus Regression Regulation Of Angiogenesis Response To Growth Factor Regulation Of Protein Kinase C Signaling Peptide Modification Regulation Of Vasculature Development Vascular Endothelial Growth Factor Receptor Activity Regulation Of Protein Phosphorylation Anterograde Axonal Protein Transport Focal Adhesion Regulation Of Phosphorylation Negative Regulation Of Vascular Endothelial Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Anatomical Structure Regression Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Vascular Endothelial Growth Factor Signaling Pathway L-ascorbic Acid Binding Positive Regulation Of Locomotion Monocyte Chemotaxis Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Protein Refolding Positive Regulation Of MAP Kinase Activity Sprouting Angiogenesis Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Motility Growth Factor Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Migration Regulation Of Locomotion
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