CCNF and CCNB1

Number of citations: 57 (PubMedID 10716937)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		CCNF	CCNB1
Name		cyclin F	cyclin B1
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Cyclin B1-CDK1 Complex
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Placenta Development Negative Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Cell Cycle	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Toxic Substance Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerization of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2 Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
GWAS		Height ( 28552196 ) Triglyceride levels ( 32203549 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: AKT1 CCNB1 E2F1 E2F2 E2F3 FZR1 MYBL2 RBPJ SCYL1 SQSTM1	64 interacting genes: ANAPC11 ARID4A BRCA1 BTG2 CCNB1IP1 CCNF CDC25A CDC25C CDC34 CDC6 CDH1 CDK1 CDKN1A CDKN1B CDT1 CEBPA CSNK2B CUX1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 KPNB1 MAP4 MEF2C MOK NACC1 OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 PRC1 PRKDC PTCH1 PTMA RALBP1 RB1 RUNX2 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D UCHL3 USP39 WEE1 XIAP XRCC6 ZFAND5
Entrez ID		899	891
HPRD ID		02574	00454
Ensembl ID		ENSG00000162063	ENSG00000134057
Uniprot IDs		P41002 Q59HD0	P14635
PDB IDs		9CB3	2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 7NJ0 8TAR 8TAU 9FH9
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Lens Fiber Cell Apoptotic Process Positive Regulation Of Organ Growth Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Positive Regulation Of Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm Regulation Of Organ Growth Anoikis Regulation Of Mitotic Cell Cycle Phase Transition Protein Import Into Nucleus Import Into Nucleus Nucleus Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Labyrinthine Layer Blood Vessel Development Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Biosynthetic Process Regulation Of RNA Metabolic Process Anaphase-promoting Complex-dependent Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Phase Transition DNA-binding Transcription Activator Activity Cellular Response To Oxygen Levels Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Positive Regulation Of Developmental Growth Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Placenta Blood Vessel Development Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Protein Ubiquitination	Regulation Of Cell Cycle Nucleoplasm Nucleus Regulation Of Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Replication Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Signal Transduction In Response To DNA Damage Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Positive Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Cell Division DNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of DNA Metabolic Process Cyclin Binding Regulation Of Kinase Activity DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process