FH and CSTPP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FH	CSTPP1
Name		fumarate hydratase	centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Microtubule Cytoskeleton Organization Microtubule Polymerization Cilium Disassembly Regulation Of Protein Complex Stability
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation	None
Diseases		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Major depressive disorder ( 27479909 ) Metabolite levels ( 23823483 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	19 interacting genes: ARHGEF15 CDC16 ENY2 FH GCA GSR PHF1 PNMA5 PRKAR1A PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A TXN2 UBE3A UBQLN4 ZFHX3
Entrez ID		2271	79096
HPRD ID		00652	08332
Ensembl ID		ENSG00000091483	ENSG00000149179
Uniprot IDs		A0A0S2Z4C3 P07954	B4DUV7 Q9H6J7
PDB IDs		3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB	Not available
GO Terms Enriched among Interactors		Non-canonical Inflammasome Complex Assembly	None