FH and MDH2

Number of citations of the paper that reports this interaction (PMID 2759092)
1

Data Source:
HPRD (in vitro)

		FH	MDH2
Gene Name		fumarate hydratase	malate dehydrogenase 2, NAD (mitochondrial)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Tricarboxylic Acid Cycle Enzyme Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Fumarate Hydratase Activity	L-malate Dehydrogenase Activity Protein Self-association Poly(A) RNA Binding Malate Dehydrogenase (NADP+) Activity
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Homeostasis Of Number Of Cells Within A Tissue	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Pathogenesis Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of carbohydrates Citric acid cycle (TCA cycle)
Drugs			NADH Citric Acid
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GRB2 MDH2 PIM1	7 interactors: CRYAB CS FH GOT2 NDUFS1 PC WARS
Entrez ID		2271	4191
HPRD ID		00652	01099
Ensembl ID		ENSG00000091483	ENSG00000146701
Uniprot IDs		B1ANK7 P07954	B3KTM1 B4DE44 E9PDB2 G3XAL0 P40926
PDB IDs		3E04	2DFD
Enriched GO Terms of Interacting Partners?			Fumarate Metabolic Process Dicarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Oxaloacetate Metabolic Process Cellular Respiration Tricarboxylic Acid Cycle Energy Derivation By Oxidation Of Organic Compounds Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Generation Of Precursor Metabolites And Energy Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Glucose Metabolic Process Carbohydrate Biosynthetic Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Pathogenesis Hexose Metabolic Process Glutamate Catabolic Process Aspartate Metabolic Process Tubulin Complex Assembly Monosaccharide Metabolic Process Carbohydrate Metabolic Process Cellular Metabolic Process Biotin Metabolic Process Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process 2-oxoglutarate Metabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Apoptotic Process Involved In Development Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Membrane Potential Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Monocarboxylic Acid Metabolic Process Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		actual adh adh2 alcohol american americans amplitude confer dependence electrophysiological erp heritage indian influenced ingestion intense metabolizing mission nah native p3 p3a p3b perhaps placebo replicate scalp tribes vulnerability	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		actual adh adh2 alcohol american americans amplitude confer dependence electrophysiological erp heritage indian influenced ingestion intense metabolizing mission nah native p3 p3a p3b perhaps placebo replicate scalp tribes vulnerability	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?