FH and LMNB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FH	LMNB2
Description		fumarate hydratase	lamin B2
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Site Of Double-strand Break Extracellular Exosome	Nucleus Nuclear Envelope Nuclear Lamina Intermediate Filament Nuclear Membrane
	Molecular Function	Catalytic Activity Fumarate Hydratase Activity Protein Binding Lyase Activity Histone Binding	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding
	Biological Process	Urea Cycle Regulation Of Arginine Metabolic Process Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Arginine Metabolic Process DNA Damage Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs
Diseases		Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency Multiple cutaneous and uterine leiomyomata Renal cell carcinoma
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: CCDC102B CCDC57 CCNDBP1 CSTPP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 OGT PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	28 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3
Entrez ID		2271	84823
HPRD ID		00652	01037
Ensembl ID		ENSG00000091483	ENSG00000176619
Uniprot IDs		A0A0S2Z4C3 P07954	Q03252
PDB IDs		3E04 5D6B 5UPP 6EBT 6V8F 6VBE 7LUB	2LLL
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly	Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Regulation Of Actin Filament Organization Cytoplasm Regulation Of Autophagy Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription
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