CRY2 and NADK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRY2	NADK
Description		cryptochrome circadian regulator 2	NAD kinase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex	Cytosol
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding	Nucleotide Binding NAD+ Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	NADP+ Biosynthetic Process Phosphorylation NAD+ Metabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ATP Metabolic Process
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins	Nicotinate metabolism
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)	Blood protein levels ( 30072576) Body mass index ( 26426971 28892062) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Multiple sclerosis ( 31604244) Pulse pressure ( 28135244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28135244 30578418)
Interacting Genes		53 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42	10 interacting genes: CRY2 EEF1G FAM124B GLRX3 GRB2 LNX1 NUDT18 SDCBP SRPK2 YWHAQ
Entrez ID		1408	65220
HPRD ID		07226	16907
Ensembl ID		ENSG00000121671	ENSG00000008130
Uniprot IDs		A0A0D2X7Z3 A2I2P1 Q49AN0	A0A0A0MR98 O95544
PDB IDs			3PFN 8KGC 9CR3 9CR4 9CRA
Enriched GO Terms of Interacting Partners?		Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition	Photoreactive Repair Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Grb2-EGFR Complex Ras Protein Signal Transduction Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex 14-3-3 Protein Binding 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process GDP Catabolic Process Negative Regulation Of Transport Cry-Per Complex 8-oxo-dGDP Phosphatase Activity Identical Protein Binding Intracellular Signal Transduction Negative Regulation Of Glucocorticoid Secretion Cytosol Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Nuclear Speck Organization Regulation Of Sodium-dependent Phosphate Transport
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