CRY2 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		CRY2	NPAS2
Description		cryptochrome circadian regulator 2	neuronal PAS domain protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol CLOCK-BMAL Transcription Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Response To Xenobiotic Stimulus Regulation Of Gene Expression Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Rhythmic Process Response To Redox State Positive Regulation Of Behavioral Fear Response
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)	Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31798171 31959993) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		53 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42	29 interacting genes: ARNT ARNT2 BMAL1 BPIFA1 CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1
Entrez ID		1408	4862
HPRD ID		07226	09137
Ensembl ID		ENSG00000121671	ENSG00000170485
Uniprot IDs		A0A0D2X7Z3 A2I2P1 Q49AN0	A2I2P5 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition	Chromatin Transcription Regulator Complex Intracellular Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Nuclear Receptor Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of DNA-templated Transcription Aryl Hydrocarbon Receptor Binding Regulation Of RNA Biosynthetic Process Aryl Hydrocarbon Receptor Complex Rhythmic Process Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor Activity DNA Binding Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Acetyltransferase Activity Hormone-mediated Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?