CRY2 and PER3

Number of citations of the paper that reports this interaction (PMID 14701732)
33

Data Source:
HPRD (in vitro)

		CRY2	PER3
Gene Name		cryptochrome circadian clock 2	period circadian clock 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding Ubiquitin Binding FAD Binding	Signal Transducer Activity Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoreactive Repair Transcription, DNA-templated Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Circadian Regulation Of Gene Expression Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Visceral fat ( 22589738)
Protein-Protein Interactions		11 interactors: ATXN1 BRCA1 CTBP1 MTUS2 PDE9A PER1 PER2 PER3 PPP5C TIMELESS TTC1	9 interactors: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1
Entrez ID		1408	8863
HPRD ID		07226	09138
Ensembl ID		ENSG00000121671	ENSG00000049246
Uniprot IDs		B4DZD6 Q49AN0	A2I2N5 P56645
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Regulation Of Circadian Rhythm Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Rhythmic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Histone Acetylation White Fat Cell Differentiation Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3 Deacetylation Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Acetylation Nitrogen Compound Metabolic Process Histone Deacetylation Protein Deacetylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Modification Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Chromosome Organization Organelle Organization Response To Radiation Response To Abiotic Stimulus Negative Regulation Of Fat Cell Proliferation	Circadian Regulation Of Gene Expression Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Photoperiodism Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Hair Cycle Entrainment Of Circadian Clock Blue Light Signaling Pathway Regulation Of Signal Transduction Response To Blue Light Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Circadian Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Hormone Secretion Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Signaling Cell Communication RNA Biosynthetic Process Response To Light Stimulus Regulation Of Type B Pancreatic Cell Development Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stimulus Protein-chromophore Linkage Response To Radiation Cellular Response To Radiation Positive Regulation Of Wnt Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		aiming arntl2 circadian clinicopathological clock clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker	aanat2 bmal1 bmal1b circadian clock cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish
Tagcloud (Difference) ?		aiming arntl2 clinicopathological clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 progressed rhythm rorc stratification stronger systematically weaker	aanat2 bmal1 bmal1b cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b period2 represses rev roralpha rore talen vertebrate zebrafish
Tagcloud (Intersection) ?		circadian clock per2 per3