IP6K2 and PLSCR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		IP6K2	PLSCR1
Gene Name		inositol hexakisphosphate kinase 2	phospholipid scramblase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Inositol Hexakisphosphate 5-kinase Activity ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Phosphate Ion Transport Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Type I Interferon Signaling Pathway	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		Synthesis of IPs in the nucleus Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Inositol phosphate metabolism
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: HSP90AA1 MEOX2 PLSCR1 RBPMS	125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764
Entrez ID		51447	5359
HPRD ID		07380	08855
Ensembl ID		ENSG00000068745	ENSG00000188313
Uniprot IDs		B2RCP4 Q9UHH9	B4DTE8 O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Protein Import Into Mitochondrial Outer Membrane Somite Specification Phosphatidylserine Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Regulation Of Nitrogen Compound Metabolic Process Chaperone-mediated Protein Complex Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Segment Specification Nitrogen Compound Metabolic Process Response To Interferon-beta Protein Refolding Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Immune Response Nitric Oxide Metabolic Process Phosphatidylserine Metabolic Process Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Positive Regulation Of ATPase Activity Regulation Of Mast Cell Activation Regulation Of Nitric-oxide Synthase Activity Acute-phase Response Regulation Of ATPase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Membrane Organization Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Immune Response Negative Regulation Of Viral Genome Replication Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process Intracellular Protein Transmembrane Transport RNA Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Metabolic Process Protein Transmembrane Transport Mitochondrial Membrane Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Targeting To Mitochondrion Cellular Response To Heat Cell Death Gene Expression	Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation
Tagcloud ?		actions apoptotic atm cascade ck2 cochaperone diphosphoinositol hexakisphosphate inositol ip6ks ip7 kinases linking pentakisphosphate phosphoinositide pikks pkcs pyrophosphates require serine stabilized stabilizing stimulates tel2 thereby tti1 tti2 ttt whose	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Difference) ?		apoptotic atm cascade ck2 cochaperone diphosphoinositol hexakisphosphate inositol ip6ks ip7 kinases linking pentakisphosphate phosphoinositide pikks pkcs pyrophosphates require serine stabilized stabilizing stimulates tel2 thereby tti1 tti2 ttt whose	adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Intersection) ?		actions