DEF8

Description		differentially expressed in FDCP 8 homolog
Image		No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Lysosome Localization Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Basal cell carcinoma ( 33549134) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Red vs. brown/black hair color ( 30531825) Squamous cell carcinoma ( 26829030 26908436)
Interacting Genes		7 interacting genes: CFTR MEOX2 RSPH1 TRIM55 TRIM63 ZNF417 ZNF587
Entrez ID		54849
HPRD ID		07882
Ensembl ID		ENSG00000140995
Uniprot IDs		Q6ZN54
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Somite Specification Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Outer Dense Fiber Radial Spoke Head Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Muscle Atrophy
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