QKI and MBNL2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		QKI	MBNL2
Description		QKI, KH domain containing RNA binding	muscleblind like splicing regulator 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process	MRNA Processing RNA Splicing Regulation Of RNA Splicing
Pathways		Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)	Alcoholism (alcohol dependence factor score) ( 21529783) Alcoholism (alcohol use disorder factor score) ( 21529783) Diastolic blood pressure ( 30224653) Energy expenditure (24h) ( 28476931) Lung function in heavy smokers (high FEV1 vs average FEV1) ( 26423011) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet reactivity in response to clopidogrel treatment ( 32472697) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5	5 interacting genes: MSI2 QKI RBPMS SNRPA TIAL1
Entrez ID		9444	10150
HPRD ID		06691	09543
Ensembl ID		ENSG00000112531	ENSG00000139793
Uniprot IDs		Q8WY44 Q96PU8	A0A7P0T9I3 A0A994J506 A0A994J509 A2A3S3 Q5VZF2
PDB IDs		4JVH	2E5S 2RPP
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process	Nucleic Acid Binding Cytoplasmic Stress Granule RNA Binding MRNA 3'-UTR Binding MRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of MRNA Splicing, Via Spliceosome Myofibroblast Contraction Regulation Of MRNA Processing Negative Regulation Of MiRNA Catabolic Process Spliceosomal SnRNP Complex RNA Processing Protein-RNA Adaptor Activity Regulation Of RNA Splicing Spliceosome-depend Formation Of Circular RNA MRNA CDS Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of 3'-UTR-mediated MRNA Stabilization U1 SnRNA Binding U1 SnRNP Binding Microglia Differentiation Negative Regulation Of Macrophage Differentiation Transcription Coactivator Activity Vascular Associated Smooth Muscle Cell Differentiation Cytolytic Granule Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of MRNA Metabolic Process Intracellular MRNA Localization Pre-mRNA Intronic Binding RNA Splicing U1 SnRNP Regulation Of Translation Positive Regulation Of Myelination Pre-mRNA Binding MRNA Processing Positive Regulation Of Hippo Signaling Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Oligodendrocyte Differentiation Poly(U) RNA Binding Regulation Of Macrophage Differentiation SMAD Protein Signal Transduction Identical Protein Binding Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Smooth Muscle Cell Differentiation Regulation Of Astrocyte Differentiation Stress Granule Assembly RNA Localization Regulation Of Cholesterol Biosynthetic Process
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