VAMP7 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 12853575)
39

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		VAMP7	SNAP25
Description		vesicle associated membrane protein 7	synaptosome associated protein 25
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Lamellipodium Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Platelet Alpha Granule Pseudopodium SNARE Complex Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Neuron Projection Synapse Phagocytic Vesicle Extracellular Exosome Plasma Membrane Bounded Cell Projection	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Phagocytosis, Engulfment Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Autophagosome Maturation Positive Regulation Of Histamine Secretion By Mast Cell	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis
Pathways		trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Interleukin-12 signaling	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs			Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS			Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		12 interacting genes: AGFG1 ANKRD27 AP3D1 CALM1 DNAJC5 SNAP23 SNAP25 SNAP29 STX1A STX3 STX4 STX7	45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		6845	6616
HPRD ID		02084	02637
Ensembl ID		ENSG00000124333	ENSG00000132639
Uniprot IDs		P51809	P60880
PDB IDs		2DMW	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport SNARE Binding Membrane Fusion Vesicle-mediated Transport In Synapse Exocytosis Establishment Of Localization In Cell Organelle Localization Synaptic Vesicle Membrane Organization Vesicle Docking Membrane Organization Secretion By Cell Secretion Positive Regulation Of Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Azurophil Granule Long-term Synaptic Potentiation Neuron Projection Protein Transport Specific Granule Synaptic Vesicle Priming Presynapse Establishment Of Protein Localization Neurotransmitter Transport Endomembrane System Synaptic Vesicle Exocytosis Synaptic Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Signal Release Intracellular Transport Intracellular Protein Localization Organelle Organization Syntaxin Binding Regulation Of Synaptic Plasticity Autophagosome Membrane Docking ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Cytoplasmic Vesicle Modulation Of Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Intracellular Protein Transport Endosome To Melanosome Transport	SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport
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