VAMP7 and ANKRD27

Number of citations of the paper that reports this interaction (PubMedID 19745841)
33

Data Source:
BioGRID (pull down, affinity chromatography technology)

		VAMP7	ANKRD27
Description		vesicle associated membrane protein 7	ankyrin repeat domain 27
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Lamellipodium Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Platelet Alpha Granule Pseudopodium SNARE Complex Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Neuron Projection Synapse Phagocytic Vesicle Extracellular Exosome Plasma Membrane Bounded Cell Projection	Lysosome Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Melanosome Neuron Projection Tubular Endosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	SNARE Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Phagocytosis, Engulfment Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Autophagosome Maturation Positive Regulation Of Histamine Secretion By Mast Cell	Positive Regulation Of Neuron Projection Development Protein Transport Endocytic Recycling Negative Regulation Of SNARE Complex Assembly Endosome To Melanosome Transport Early Endosome To Late Endosome Transport Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis
Pathways		trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Interleukin-12 signaling	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Eosinophilic esophagitis ( 25407941) Gut microbiota relative abundance (Bacteroides) ( 33208821) Major depressive disorder ( 23377640) Red cell distribution width ( 27863252 28957414) Systemic lupus erythematosus ( 33536424)
Interacting Genes		12 interacting genes: AGFG1 ANKRD27 AP3D1 CALM1 DNAJC5 SNAP23 SNAP25 SNAP29 STX1A STX3 STX4 STX7	5 interacting genes: RAB40A RAB40B RAB40C SMAD1 VAMP7
Entrez ID		6845	84079
HPRD ID		02084	10650
Ensembl ID		ENSG00000124333	ENSG00000105186
Uniprot IDs		P51809	Q96NW4
PDB IDs		2DMW	4B93 4CYM 4CZ2 6TL0
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport SNARE Binding Membrane Fusion Vesicle-mediated Transport In Synapse Exocytosis Establishment Of Localization In Cell Organelle Localization Synaptic Vesicle Membrane Organization Vesicle Docking Membrane Organization Secretion By Cell Secretion Positive Regulation Of Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Azurophil Granule Long-term Synaptic Potentiation Neuron Projection Protein Transport Specific Granule Synaptic Vesicle Priming Presynapse Establishment Of Protein Localization Neurotransmitter Transport Endomembrane System Synaptic Vesicle Exocytosis Synaptic Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Signal Release Intracellular Transport Intracellular Protein Localization Organelle Organization Syntaxin Binding Regulation Of Synaptic Plasticity Autophagosome Membrane Docking ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Cytoplasmic Vesicle Modulation Of Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Intracellular Protein Transport Endosome To Melanosome Transport	Exocytosis Secretion By Cell Ubiquitin-like Ligase-substrate Adaptor Activity Secretion Synaptic Vesicle Cul5-RING Ubiquitin Ligase Complex Endosome GTPase Activity GTP Binding Vesicle-mediated Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell-substrate Junction Organization Lipid Droplet Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Homomeric SMAD Protein Complex Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Component Organization Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Negative Regulation Of Focal Adhesion Disassembly Post-translational Protein Modification Positive Regulation Of Histamine Secretion By Mast Cell Lamellipodium Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Component Organization SMAD Protein Complex Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Macromolecule Catabolic Process Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Primary MiRNA Binding Proteolysis Co-SMAD Binding Cell Fate Commitment Involved In Formation Of Primary Germ Layer Primary MiRNA Processing Golgi Apparatus Positive Regulation Of Dendrite Development Positive Regulation Of Mast Cell Degranulation I-SMAD Binding Cardiac Conduction System Development Lipid Droplet Formation
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