CDK3 and CCNE2

Number of citations of the paper that reports this interaction (PubMedID 9840943)
0

Data Source:
HPRD (two hybrid)

		CDK3	CCNE2
Description		cyclin dependent kinase 3	cyclin E2
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Signal Transduction Cell Population Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS			Keratoconus ( 33649486)
Interacting Genes		38 interacting genes: APP CABLES1 CABLES2 CCNA2 CCNC CCND3 CCNE1 CCNE2 CCNH CCNI CDC37 CDKN1A CDKN1B CDKN3 CKS2 E2F1 E2F2 E2F3 FOXP2 FRS2 KIR3DL1 LHX3 LHX4 MEOX2 NEDD4L NELFA OR2G6 OTX2 PAX5 PAX6 PAX8 PPARA RACGAP1 RB1 SPDYE4 STN1 TRIM55 TRIM63	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1018	9134
HPRD ID		00446	04801
Ensembl ID		ENSG00000250506	ENSG00000175305
Uniprot IDs		Q00526	O96020
PDB IDs		7XQK 8H4R	8HN9
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Binding Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Rb-E2F Complex Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Division Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Regulation Of Gene Expression Epithelial Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Tissue Regeneration Medial Motor Column Neuron Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition DNA Binding Positive Regulation Of Mitotic Cell Cycle Cyclin E1-CDK2 Complex Regulation Of Protein Kinase Activity	Cyclin Binding Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of DNA Replication Ubiquitin Protein Ligase Binding Molecular Function Inhibitor Activity Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Inhibitor Activity Positive Regulation Of Protein Catabolic Process Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Protein Tag Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Exit From Mitosis Negative Regulation Of Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Epithelial Cell Proliferation
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